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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease
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Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease

机译：面筋敏感型肠病与猕猴腹腔疾病模型中肠道T细胞分泌IL-17和IL-22的能力下降相吻合

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摘要

Celiac disease (CD) is an autoimmune disorder caused by intolerance to dietary gluten. The interleukin (IL)-17 and IL-22 function as innate regulators of mucosal integrity. Impaired but not well-understood kinetics of the IL-17/22 secretion was described in celiac patients. Here, the IL-17 and IL-22-producing intestinal cells were studied upon their in vitro stimulation with mitogens in class II major histocompatibility complex-defined, gluten-sensitive rhesus macaques. Pediatric biopsies were collected from distal duodenum during the stages of disease remission and relapse. Regardless of dietary gluten content, IL-17 and IL-22-producing cells consisted of CD4. + and CD8. + T lymphocytes as well as of lineage-negative (Lin. -) cells. Upon introduction of dietary gluten, capability of intestinal T cells to secrete IL-17/22 started to decline (p< 0.05), which was paralleled with gradual disruption of epithelial integrity. These data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
机译：腹腔疾病（CD）是由对饮食麸质的不耐受引起的自身免疫性疾病。白介素（IL）-17和IL-22充当粘膜完整性的先天调节剂。在乳糜泻患者中描述了IL-17 / 22分泌受损但尚未很好理解的动力学。在这里，研究了产生IL-17和IL-22的肠道细胞在体外用II类主要组织相容性复合物定义的，对麸质敏感的猕猴的有丝分裂原刺激的过程。在疾病缓解和复发阶段从十二指肠远端收集儿科活检。无论膳食面筋含量如何，产生IL-17和IL-22的细胞均由CD4组成。 +和CD8。 + T淋巴细胞以及谱系阴性（淋巴结-）细胞。引入膳食面筋后，肠道T细胞分泌IL-17 / 22的能力开始下降（p <0.05），这与上皮完整性的逐渐破坏相平行。这些数据表明产生IL-17 / 22的细胞在面筋敏感灵长类动物的肠粘膜维持中起重要作用。

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