Human immunoglobulin constant heavy G chain (IGHG) (Fcgamma) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy

Vivi-Anne Oxelius; Janardan P. Pey

首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Human immunoglobulin constant heavy G chain (IGHG) (Fcgamma) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy

【24h】

Human immunoglobulin constant heavy G chain (IGHG) (Fcgamma) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy

机译：人免疫球蛋白恒定重链（IGHG）（Fcgamma）（GM）基因定义了IgG分子和B细胞的先天变异体，对疾病和治疗有影响

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Abstract The distinguished alternative GM allotypes localized in immunoglobulin constant heavy G chain IGHG (FC7) (GM) genes on chromosome 14q32.3 define two unique variants of respectively lgG3, IgG1 and lgG2 subclasses, with different structures and functions. The IGHG allele (allotypes), expressed In homozygous or heterozygous forms, are assessed by new serological methods. Fixed combinations of gamma3, gamma1 and gamma2 allotypes constitute the haplotypes, which are indirect markers of B cells. We highlight the role of homozygous IGHG genes with restricted qualities of IgG subclass molecules and B cells. These common Mendelian IGHG genes respond differently to allergens and infections, both bacterial and viral, and to active and passive immunotherapies. IGHG genes have an impact on diseases such as allergy, immunodeficiency, autoimmunity and malignancy. Association/linkage of different IGHG genes gives information about risk/protection, good or bad prognosis, for improvement of clinical care. The IGHG gene map of healthy Caucasians is registered.

机译：摘要位于染色体14q32.3上的免疫球蛋白恒定重G链IGHG（FC7）（GM）基因中的独特替代GM同种异型分别定义了lgG3，IgG1和lgG2亚类的两个独特变体，具有不同的结构和功能。通过新的血清学方法评估以纯合或杂合形式表达的IGHG等位基因（异型）。 γ3，γ1和γ2同种异型的固定组合构成单倍型，其是B细胞的间接标记。我们强调了纯合性IGHG基因在IgG亚类分子和B细胞的限制性质量中的作用。这些常见的孟德尔IGHG基因对细菌和病毒的过敏原和感染以及主动和被动免疫疗法的反应不同。 IGHG基因对过敏，免疫缺陷，自身免疫和恶性肿瘤等疾病有影响。不同IGHG基因的关联/链接可提供有关风险/保护，预后好坏的信息，以改善临床护理。已注册健康高加索人的IGHG基因图谱。

著录项

来源
《Clinical immunology: The official journal of the Clinical Immunology Society》 |2013年第2期|共12页
作者
Vivi-Anne Oxelius; Janardan P. Pey;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
IGHG (FC7) (GM) genes; innate IgG molecules and B cells; IgG related diseases; Active and passive immunotherapies;

机译：IGHG（FC7）（GM）基因;先天IgG分子和B细胞;IgG相关疾病;主动和被动免疫疗法;

相似文献

外文文献
中文文献
专利

1. Human immunoglobulin constant heavy G chain (IGHG) (Fcgamma) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy [J] . Vivi-Anne Oxelius, Janardan P. Pey Clinical immunology: The official journal of the Clinical Immunology Society . 2013,第3aPta2期

机译：人免疫球蛋白恒定重链（IGHG）（Fcgamma）（GM）基因定义了IgG分子和B细胞的先天变异体，对疾病和治疗有影响
2. From genotypes of immunoglobulin constant heavy G chains (Fcγ) (GM) genes (IGHG) to phenotypes in childhood asthma [J] . OxeliusV.-A. International archives of allergy and immunology . 2012,第1期

机译：从免疫球蛋白恒定重G链（Fcγ）（GM）基因（IGHG）的基因型到儿童哮喘的表型
3. Baboon immunoglobulin constant region heavy chains: identification of four IGHG genes [J] . Roberta Attanasio, Lakshmi Jayashankar, Carrie N. Engleman, Immunogenetics . 2002,第8期

机译：狒狒免疫球蛋白恒定区重链：四个IGHG基因的鉴定
4. A novel approach to control and regulate the classical complement pathway: Highly specific inhibition of C1q globular head binding to human IgG using an engineered single chain antibody variable fragment; recruiting C1q to HER2 /neu positive cells using truncated bispecific antibodies [D] . Hwang, Hee Young 2007

机译：一种控制和调节经典补体途径的新方法：使用工程化的单链抗体可变片段高度特异性地抑制C1q球头与人IgG的结合；使用截短的双特异性抗体将C1q募集到HER2 / neu阳性细胞
5. Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection [O] . Verónica Calonga-Solís, Danielle Malheiros, Marcia Holsbach Beltrame, -1

机译：在巴西人群中揭示免疫球蛋白重恒定伽玛（IGHG）基因片段的多样性揭示了28个新等位基因以及基因转化和自然选择的证据
6. Human immunoglobulin constant heavy G chain (IGHG) (Fcγ) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy. [O] . Oxelius, Vivi-Anne, Pandey, Janardan P 2013

机译：人免疫球蛋白恒定重链G（IGHG）（Fcγ）（Gm）基因，定义IgG分子和B细胞的先天变体，对疾病和治疗有影响。

Human immunoglobulin constant heavy G chain (IGHG) (Fcgamma) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy

摘要

著录项

相似文献

相关主题

期刊订阅