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首页> 外文期刊>Journal of plastic, reconstructive & aesthetic surgery: JPRAS >Use of botulinum toxin type A to improve treatment of facial wounds: A prospective randomised study
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Use of botulinum toxin type A to improve treatment of facial wounds: A prospective randomised study

机译：使用A型肉毒毒素改善面部伤口的治疗：一项前瞻性随机研究

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Background: The tension vectors acting on the wound edges are transmitted to immature collagen fibres synthesised during the normal healing phase. This accounts for scar widening as well as hypertrophic and hyperpigmented scars. The aim of our study was to evaluate whether early injections of botulinum toxin type A (BTA), which induces temporary muscular paralysis, decreases tension vectors on wound edges and enhances scarring of facial wounds. Patients and methods: Thirty patients with facial wounds were enrolled in this study and randomised into two groups with or without injection of BTA within 72 h postoperatively. BTA was injected into the facial muscles directly or indirectly involved in scar widening. Scars were assessed at a 1-year follow-up visit by patients using the Patient Scar Assessment Scale (PSAS) scale, by an independent evaluator using the Observer Scar Assessment Scale (OSAS) and the Vancouver Scar Scale (VSS), and by a board of six experienced medical specialists using the Visual Analogue Scale (VAS) with standardised photographs. Results: At the 1-year visit, 24 patients were reviewed and six patients were lost to follow-up. No statistically significant differences were found between the two groups for the PSAS, OSAS and VSS scores. However, the median VAS rated by the six evaluators was 8.25 for the botulinum toxin-treated group compared with 6.35 for the control group. This result was statistically different, demonstrating improved scarring with BTA. Conclusions: Thanks to chemoimmobilisation, injections of BTA appear to improve cosmesis of facial wounds. Accordingly, they would be beneficial for use in young patients for wounds without tissue loss, lying perpendicular to the reduced tension lines of the skin of the face.
机译：背景：作用在伤口边缘的张力向量被传递到正常愈合阶段合成的未成熟胶原纤维。这导致疤痕增宽以及肥厚和色素沉着的疤痕。我们研究的目的是评估早期注射A型肉毒杆菌毒素（BTA）是否会引起暂时性肌肉麻痹，减少伤口边缘的张力向量并增加面部伤口的疤痕形成。患者和方法：30例面部伤口患者参加了这项研究，并在术后72小时内随机分为两组，有或没有注射BTA。 BTA直接或间接注射到面部肌肉中，与疤痕增宽有关。病人在1年的随访中使用患者疤痕评估量表（PSAS）评估疤痕，由独立评估员使用观察者疤痕评估量表（OSAS）和温哥华疤痕量表（VSS）评估疤痕。由六名经验丰富的医学专家组成的委员会，他们使用视觉模拟量表（VAS）和标准化照片。结果：在为期1年的随访中，对24例患者进行了回顾，有6例患者失访。两组之间在PSAS，OSAS和VSS评分上没有发现统计学上的显着差异。然而，肉毒杆菌毒素治疗组的六位评估者评定的VAS中位数为8.25，而对照组为6.35。该结果在统计学上是不同的，表明BTA瘢痕形成得到改善。结论：由于化学固定，注射BTA似乎可以改善面部伤口的美容效果。因此，它们将有利于年轻患者用于垂直于面部皮肤张力降低线而无组织损失的伤口。

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