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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Anti-tumor effects of inactivated Sendai virus particles with an IL-2 gene on angiosarcoma
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Anti-tumor effects of inactivated Sendai virus particles with an IL-2 gene on angiosarcoma

机译：IL-2基因灭活的仙台病毒颗粒对血管肉瘤的抗肿瘤作用

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摘要

Cutaneous angiosarcoma is a life-threatening tumor that is resistant to conventional therapies. The therapeutic effects of Sendai virus particles (hemagglutinating virus of Japan envelope: HVJ-E) carrying IL-2 gene (HVJ-E/IL-2) were examined in a mouse model of angiosarcoma. Intra-tumoral injection of HVJ-E/IL-2 effectively inhibited the growth of angiosarcoma cells (ISOS-1) inoculated in mice and improved tumor-free rates. HVJ-E/IL-2 stimulated local accumulation of CD8 (+) T cells and NK cells and reduced regulatory T cells in regional lymph nodes. Notably, the prevalence of myeloid-derived suppressor cells was lower in HVJ-E/IL-2-treated mice than in HVJ-E-treated mice. HVJ-E/IL-2 treatment promoted IFN-γ production from CD8 (+) T cells in response to tumor cells, more significantly than HVJ-E treatment. Greatly improved tumor-free rates were obtained when sunitinib, a tyrosine kinase inhibitor, was administered in combination with HVJ-E/IL-2. Immunogene therapy with HVJ-E/IL-2 with or without sunitinib could be a promising therapeutic option for cutaneous angiosarcoma.
机译：皮肤血管肉瘤是一种威胁生命的肿瘤，对常规疗法具有抵抗力。在血管肉瘤的小鼠模型中检查了携带IL-2基因（HVJ-E / IL-2）的仙台病毒颗粒（日本包膜血凝病毒：HVJ-E）的治疗效果。瘤内注射HVJ-E / IL-2可有效抑制小鼠中接种的血管肉瘤细胞（ISOS-1）的生长并提高无瘤率。 HVJ-E / IL-2刺激CD8（+）T细胞和NK细胞的局部积累，并减少区域淋巴结中的调节性T细胞。值得注意的是，在HVJ-E / IL-2处理的小鼠中，髓样来源的抑制细胞的发生率比在HVJ-E处理的小鼠中低。 HVJ-E / IL-2处理促进CD8（+）T细胞响应肿瘤细胞产生IFN-γ，比HVJ-E处理更显着。当将舒尼替尼（一种酪氨酸激酶抑制剂）与HVJ-E / IL-2组合使用时，可显着提高无肿瘤率。 HVJ-E / IL-2联合或不联合舒尼替尼的免疫原性治疗可能是皮肤血管肉瘤的有前途的治疗选择。

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