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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells
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Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells

机译：乳酸乳球菌JCM5805对人浆细胞样树突状细胞的免疫调节作用

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Abstract Plasmacytoid dendritic cells (pDCs) play a crucial role in anti-viral immunity through production of large amounts of interferons (IFNs). A previous study revealed the existence of lactic acid bacteria that directly stimulate pDCs in mice. In this study, we demonstrated that Lactococcus lactis JCM5805 activates human pDCs and induces IFN production in vitro. In addition, our randomized, placebo-controlled, double blind test showed that yogurt fermented with L. lactis JCM5805 activated pDC activity in vivo. This effect was greater in low pDC subjects, and their ability to produce IFNs was increased from the beginning. Furthermore, the risk of morbidity from the common cold was suppressed in the L. lactis JCM5805 group compared with the placebo group. In conclusion, intake of L. lactis JCM5805 can directly activate pDCs and increase the ability to produce IFNs in vivo. Therefore, L. lactis JCM5805 may be a beneficial tool to enhance anti-viral immunity in humans.
机译：摘要浆细胞样树突状细胞（pDC）通过产生大量干扰素（IFN）在抗病毒免疫中起着至关重要的作用。先前的研究揭示了直接刺激小鼠中pDC的乳酸菌的存在。在这项研究中，我们证明了乳酸乳球菌JCM5805在体外激活人pDC并诱导IFN的产生。此外，我们的随机，安慰剂对照，双盲试验显示，乳酸乳球菌JCM5805发酵的酸奶在体内可激活pDC活性。在低pDC受试者中，这种作用更大，并且从一开始就增强了他们产生IFN的能力。此外，与安慰剂组相比，乳酸乳球菌JCM5805组的普通感冒发病风险得到了抑制。总之，摄入乳酸乳球菌JCM5805可以直接激活pDC，并提高体内产生IFN的能力。因此，乳酸乳球菌JCM5805可能是增强人体内抗病毒免疫力的有益工具。

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