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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Artificial reproductive techniques in multiple sclerosis
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Artificial reproductive techniques in multiple sclerosis

机译：多发性硬化症的人工生殖技术

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Fertility does not seem to be impaired to a larger extent in women with MS. However, infertility and MS might just come coincidentally together and, therefore, MS patients might undergo assisted reproductive treatment (ART). Thus, during the last years different studies evaluating the effects of ART on MS relapses have been published. All of them reported an increase in annualized relapse rate after ART. Furthermore, in a recent study clinical worsening was associated with an increase in MRI activity. Putative mechanisms involved in MS worsening after ART include: temporary interruption of disease modified therapies, stressful events associated with infertility, and immunological changes induced by hormones such as increase in pro-inflammatory cytokines and anti-MOG antibodies, as well as an increase in immune cell migration across the blood-brain-barrier. Overall, neurologists should be aware of this risk and discuss the pros and cons of the procedures with MS patients.
机译：患有MS的女性的生育力似乎并未受到较大程度的损害。但是，不孕症和MS可能恰巧同时出现，因此，MS患者可能会接受辅助生殖治疗（ART）。因此，在最近几年中，已经发表了各种评估ART对MS复发的影响的研究。他们都报告抗逆转录病毒治疗后的年复发率增加。此外，在最近的研究中，临床恶化与MRI活性增加有关。 ART后MS恶化的推测机制包括：暂时中断疾病改良疗法，与不育症相关的应激事件以及激素引起的免疫学改变，例如促炎性细胞因子和抗MOG抗体的增加以及免疫的增加细胞跨血脑屏障迁移。总体而言，神经科医师应意识到这种风险，并与MS患者讨论该程序的利弊。

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