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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Differential aspects of immune cell infiltration and neurodegeneration in acute and relapse experimental autoimmune encephalomyelitis
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Differential aspects of immune cell infiltration and neurodegeneration in acute and relapse experimental autoimmune encephalomyelitis

机译：急性和复发性实验性自身免疫性脑脊髓炎的免疫细胞浸润和神经退行性变的不同方面

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Abstract Proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE) in SJL/J mice is a well-established animal model for the study of relapsing-remitting multiple sclerosis (MS). Here we investigated histomorphological differences between acute and relapse EAE in order to get further insights into the mechanisms that trigger the transition from a relapsing-remitting course to chronic-progressive disease. We found the extent of inflammation to differ in respect to the type of immune cells infiltrating the CNS and the manifestation of edema. Myelin pathology was predominated by demyelinated axons in the acute phase. In relapse EAE the extent of myelin pathology declined and was characterized by a balance between demyelinated and demyelinating nerve fibers. Axonal pathology increased with disease progression and was partly separated from myelin pathology and inflammation. The reported incisive differences between acute and relapse EAE suggest a transition from inflammatory processes to independent neurodegeneration in the disease course.
机译：摘要蛋白脂蛋白（PLP）诱导的SJL / J小鼠实验性自身免疫性脑脊髓炎（EAE）是用于研究复发缓解型多发性硬化症（MS）的成熟动物模型。在这里，我们调查了急性和复发性EAE之间的组织形态学差异，以进一步了解引发从复发-复发过程向慢性进行性疾病转变的机制。我们发现，炎症的程度在渗透到CNS的免疫细胞类型和水肿表现方面有所不同。在急性期，髓鞘病理以脱髓鞘的轴突为主。在EAE复发中，髓鞘病理的程度下降，其特征在于脱髓鞘的和脱髓鞘的神经纤维之间的平衡。轴突病理随着疾病的进展而增加，并且部分地与髓磷脂病理和炎症分开。报道的急性和复发性EAE之间的尖锐差异表明在疾病过程中从炎症过程过渡到独立的神经变性。

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