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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma
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Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma

机译：循环2型滤泡辅助性T细胞和调节性B细胞的改变是过敏性鼻炎与支气管哮喘并存的基础

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Allergic rhinitis (AR), the most common allergic disorder of the airway, is often accompanied by bronchial asthma. However, little is known about the mechanism by which AR advances to AR comorbid with bronchial asthma (AR + Asthma). To determine the pathophysiologic features of AR and AR + Asthma, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood from AR and AR + Asthma patients. The results showed polarization of Tfh2 cells within Tfh cell subsets in both AR and AR + Asthma cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR + Asthma cases. Moreover, we found significant correlations of fractional exhaled nitricoxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma. (C) 2015 The Authors. Published by Elsevier Inc.
机译：过敏性鼻炎（AR）是气道最常见的过敏性疾病，通常伴有支气管哮喘。然而，关于AR进展为AR与支气管哮喘（AR +哮喘）并存的机制了解甚少。为了确定AR和AR +哮喘的病理生理特征，我们检查了AR和AR +哮喘患者外周血中的滤泡性辅助T（Tfh）细胞和调节性B（Breg）细胞的亚群。结果显示在AR和AR +哮喘病例中，Tfh细胞亚群内的Tfh2细胞均极化。有趣的是，在AR患者中，总B细胞中的％Breg细胞减少了，而在AR +哮喘患者中，更广泛地减少了。此外，我们发现呼出的一氧化氮和血液嗜酸性粒细胞水平与每％Breg细胞的％Tfh2细胞指数有显着相关性。我们的发现表明，在Tfh2细胞倾斜的情况下Breg细胞的相对减少是AR对支气管哮喘的推定因素。 （C）2015作者。由Elsevier Inc.发布

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