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首页> 外文期刊>Journal of Parasitology >Efficacy of ivermectin versus dual infections of Haemonchus contortus and Heligmosomoides polygyrus in the mouse.
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Efficacy of ivermectin versus dual infections of Haemonchus contortus and Heligmosomoides polygyrus in the mouse.

机译：伊维菌素对小鼠中的捻转血矛线虫和多角螺旋藻的双重感染的功效。

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摘要

This report describes a novel assay for the detection of gastrointestinal anthelmintics using mice infected with Haemonchus contortus and adapted to the 1 animal/test group protocol. Mice infected with both H. contortus and Heligmosomoides polygyrus were fed ivermectin-medicated diets for 6 days. A dietary level of 0.09375 ppm was 98.1% effective against the 0- to 6-day-old abomasal stomach worm of sheep, whereas a level of 0.75 ppm reduced the 3- to 9-day-old H. polygyrus worm burden by 94.0%. H. contortus was approximately 8-fold more sensitive to ivermectin than was H. polygyrus in this model. The sensitivity of this assay rivals that of the gerbil-Trichostrongylus colubriformis model while utilizing a more economical host.
机译：这份报告描述了一种新的检测方法，用于使用感染了弯曲杆菌的小鼠进行胃肠道驱虫药的检测，并适用于1种动物/试验组的方案。接受同时感染伊维菌素的日粮喂食同时感染了Contortus和多头螺旋体的小鼠。饮食水平为0.09375 ppm的绵羊，对0至6天大的腹部胃蠕虫有效率为98.1％，而水平为0.75 ppm时，可使3至9天的多回H. polygyrus蠕虫负担减少了94.0％ 。在该模型中，捻转嗜血杆菌对伊维菌素的敏感性比polygyrus嗜伊红菌素高约8倍。该测定法的灵敏度可与沙鼠-Trichostrongylus colubriformis模型的灵敏度相媲美，同时利用了更经济的宿主。

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