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首页> 外文期刊>Journal of Parasitology >GIARDIA ASSEMBLAGES A AND B IN DIARRHEIC PATIENTS: A COMPARATIVE STUDY IN EGYPTIAN CHILDREN AND ADULTS
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GIARDIA ASSEMBLAGES A AND B IN DIARRHEIC PATIENTS: A COMPARATIVE STUDY IN EGYPTIAN CHILDREN AND ADULTS

机译：腹泻患者的贾第鞭毛虫组合A和B：埃及儿童和成人的对比研究

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摘要

Giardia duodenalis is considered the most common intestinal parasite in humans worldwide. Children are especially affected, with more severe consequences than adults. The present study was designed to determine the distribution of assemblages A and B Giardia infection in children and adults, with the use of light microscopy and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) as diagnostic procedures, and to investigate its associations with clinical and epidemiological data collected from children and adult groups. This cross-sectional study was conducted from October 2012 to October 2013 by collecting fecal samples from 200 children and 200 adults complaining of diarrhea. Samples were subjected to parasitological examination by direct wet smear and formol-ether methods. Genotyping of G. doudenalis samples was conducted by PCR-RFLP analysis. Giardia duodenalis infection caused by assemblages A and B was identified in 60 samples, 34 from children and 26 from adults. Assemblage B was detected in 38 patients (63.34%), and assemblage A was detected in 22 patients (36.66%). Assemblage A was significantly more frequent in children with age range 2-8 yr, and assemblage B was higher in children with age range 6-16 yr old. Diarrhea frequency/day and recurrences per month affected patients infected with assemblage A (P value 0.001) more frequently. Children infected with assemblage A presented significantly more severe diarrhea and dehydration than those infected with assemblage B (P value 0.001). Although both Giardia assemblages A and B were identified in children and adults, assemblage A infected younger children more frequently and was more closely related to severe clinical manifestations than assemblage B.
机译：贾第鞭毛虫被认为是全世界人类最常见的肠道寄生虫。儿童尤其受影响，其后果比成人严重。本研究旨在确定使用光学显微镜和聚合酶链反应-限制性片段长度多态性（PCR-RFLP）作为诊断程序，确定儿童和成人A和B贾第鞭毛虫感染的分布，并调查其关联性并从儿童和成人群体中收集临床和流行病学数据。该横断面研究于2012年10月至2013年10月进行，收集了200名抱怨腹泻的儿童和200名成年人的粪便样本。通过直接湿涂和甲醛-醚法对样品进行寄生虫学检查。通过PCR-RFLP分析对杜氏假单胞菌样品进行基因分型。在60个样品中鉴定出由组合A和B引起的十二指肠贾第虫感染，其中34个来自儿童，26个来自成人。在38例患者中检测到组合B（63.34％），在22例患者中检测到组合A（36.66％）。年龄在2-8岁的儿童中，组合A的频率明显更高，而年龄在6-16岁的儿童中，组合B的频率更高。腹泻频率/天和每月复发率更频繁地感染组合A（P值<0.001）的患者。感染了组合A的儿童的腹泻和脱水严重程度高于感染了组合B的儿童（P值<0.001）。尽管在儿童和成人中均发现了贾第鞭毛虫组合A和B，但组合A与组合B相比感染A的幼儿更频繁，并且与严重的临床表现更为密切相关。

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