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首页> 外文期刊>Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry >Trace element concentration differences in regions of human brain by INAA
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Trace element concentration differences in regions of human brain by INAA

机译：通过INAA在人脑区域中的微量元素浓度差异

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摘要

Studies have shown that there is a potential relationship between the levels of trace elements in cerebral tissues and neurological disorders. However, there are few publications available on the elemental composition of these tissues as well as for different regions of the brain. The aim of this study was to investigate trace element differences in various regions of the human brain from an elderly population of normal individuals. Brain samples from 31 individuals of both genders, aged 51-95 years were provided by the Brain Bank of the Brazilian Aging Study Group of the S?o Paulo University, Medical School. The tissues from the regions of the hippocampus, cerebellum and frontal, parietal, temporal, occipital cortex were dissected using a titanium knife, ground, freeze-dried and then analyzed by instrumental neutron activation analysis (INAA). Samples and element standards were irradiated with a neutron flux at the IEA-R1 nuclear research reactor for Br, Fe, K, Na, Rb, Se and Zn determinations. One-way ANOVA test (p < 0.05) was used to compare the results which showed significant differences for several elements among the brain regions. Most of our brain analysis results agreed with the literature data. The results were also submitted for brain region classification by cluster analysis.
机译：研究表明，脑组织中微量元素的含量与神经系统疾病之间存在潜在的关系。但是，关于这些组织以及大脑不同区域的元素组成的出版物很少。这项研究的目的是调查正常人的老年人口在人脑各个区域的微量元素差异。来自圣保罗大学医学院巴西老龄研究小组的脑库提供了31名年龄在51-95岁之间的男女个体的脑样本。用钛刀解剖海马，小脑和额叶，顶叶，颞叶，枕叶皮质区域的组织，研磨，冷冻干燥，然后通过仪器中子活化分析（INAA）进行分析。在IEA-R1核研究反应堆上用中子通量辐照样品和元素标准品，以测定Br，Fe，K，Na，Rb，Se和Zn。单向方差分析（p <0.05）用于比较结果，结果表明大脑区域中几种元素的差异显着。我们大多数的大脑分析结果与文献数据一致。还通过聚类分析将结果提交给脑区域分类。

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