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首页> 外文期刊>Journal of Radiation Research: Official Organ of the Japan Radiation Research Society >Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: A dose comparison study
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Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: A dose comparison study

机译：双剂量对比增强磁共振成像在明确转移性脑肿瘤放射治疗计划中明确肿瘤总体积的有用性：剂量比较研究

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The purpose of this study was to compare the size and clearness of gross tumor volumes (GTVs) of metastatic brain tumors on T1-weighted magnetic resonance images between a single dose contrast administration protocol and a double dose contrast administration protocol to determine the optimum dose of contrast-enhancement for clear delineation of GTV in stereotactic radiotherapy (SRT). A total of 28 small metastatic brain tumors were evaluated in 13 patients by intra-individual comparison of GTV measurements using single dose and double dose contrast-enhanced thin-slice (1-mm) magnetic resonance imaging (MRI). All patients had confirmed histological types of primary tumors and had undergone hypo-fractionated SRT for metastatic brain tumors. The mean tumor diameter with single dose and double dose contrast-enhancement was 12.0 ± 1.1 mm and 13.2 ± 1.1 mm respectively (P < 0.001). The mean incremental ratio (MIR) obtained by comparing mean tumor diameters was 11.2 ± 0.02 %. The mean volume of GTV-1 (single dose contrast-enhancement) and GTV-2 (double dose contrast-enhancement) was 1.38 ± 0.41 ml and 1.59 ± 0.45 ml respectively (P < 0.01). The MIR by comparing mean tumor volumes was 32.3 ± 0.4 %. The MIR of GTV-1 with < 1ml volume and GTV-1 with > 1ml volume was 41.8 ± 0.05 % and 12.4 ± 0.03 % respectively (P < 0.001). We conclude that double dose contrast-enhanced thin-slice MRI is a more useful technique than single dose contrast-enhanced thin-slice MRI, especially for clear delineation of GTVs of small metastatic brain tumors in treatment planning of highly precise SRT.
机译：这项研究的目的是比较单剂量对比剂给药方案和双剂量对比剂给药方案之间的T1加权磁共振图像上转移性脑瘤的总肿瘤体积（GTV）的大小和清除率，以确定最佳剂量立体定向放射治疗（SRT）中清晰描绘GTV的对比增强。通过使用单剂量和双剂量对比增强薄层（1 mm）磁共振成像（MRI）进行的GTV测量的个体内比较，对13例患者中总共28例小转移性脑肿瘤进行了评估。所有患者均已确认原发性肿瘤的组织学类型，并对转移性脑肿瘤进行了次分割的SRT。单剂量和双剂量对比增强的平均肿瘤直径分别为12.0±1.1 mm和13.2±1.1 mm（P <0.001）。通过比较平均肿瘤直径获得的平均增量比（MIR）为11.2±0.02％。 GTV-1（单剂量对比增强）和GTV-2（双剂量对比增强）的平均体积分别为1.38±0.41 ml和1.59±0.45 ml（P <0.01）。通过比较平均肿瘤体积的MIR为32.3±0.4％。体积小于1ml的GTV-1和体积大于1ml的GTV-1的MIR分别为41.8±0.05％和12.4±0.03％（P <0.001）。我们得出的结论是，与单剂量对比增强薄层MRI相比，双剂量对比增强薄层MRI比单剂量增强对比薄层MRI更有用，特别是在高精度SRT的治疗计划中清楚地描述小转移性脑肿瘤的GTV时。

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