Accelerator-based photoproduction of promising beta-emitters Cu-67 and Sc-47

Starovoitova Valeriia N.; Cole Philip L.; Grimm Terry L.

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Accelerator-based photoproduction of promising beta-emitters Cu-67 and Sc-47

机译：基于加速剂的有希望的β-发射体Cu-67和Sc-47的照相生产

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In this paper we discuss our experimental work in photoproducing two medically-useful radioisotopes (Zn-68(gamma,p) Cu-67 and Ca-48(gamma,n)Ca-47 -> Sc-47) using an electron linear accelerator. We further address the issues of production and separation of medical isotopes arising from photoneutron (gamma,n) and photoproton (gamma,p) reactions. While (gamma,n) reactions typically result in greater yields, separating product nuclides from the target is challenging since the chemical properties of both nuclides are identical. Although the yields of (gamma,p) reactions are typically lower than for (gamma,n), these proton-rich isotopes have the advantage that target and product nuclides belong to different chemical species allowing for more straightforward chemical separation. We conclude the paper by touching upon the dire necessity of experimentally revisiting a broad swath of photonuclear reactions in the 10- to 50-MeV regime. The very paucity of empirical cross-sectional data makes it altogether impossible to realistically predict accelerator-based photoproduction of many promising radiopharmaceuticals.

机译：在本文中，我们讨论了使用电子线性加速器光生两种医学上有用的放射性同位素（Zn-68（γ，p）Cu-67和Ca-48（γ，n）Ca-47-> Sc-47）的实验工作。我们进一步解决了由光中子（γ，n）和光子质子（γ，p）反应产生的医学同位素的生产和分离问题。尽管（γ，n）反应通常会产生更高的收率，但由于两种核素的化学性质相同，因此将产物核素与目标物分离是一项挑战。尽管（γ，p）反应的收率通常低于（γ，n）的收率，但这些富含质子的同位素具有以下优势：目标核素和产物核素属于不同的化学物种，可实现更直接的化学分离。我们通过触及在10至50 MeV范围内实验重新研究广泛的光核反应的迫切必要性来结束本文。经验横断面数据很少，因此完全不可能现实地预测许多有前途的放射性药物的基于促进剂的光产生。

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《Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry》 |2015年第1期|共6页
作者
Starovoitova Valeriia N.; Cole Philip L.; Grimm Terry L.;
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正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
关键词
Radioisotopes; Photonuclear production; Electron linac;

机译：放射性同位素;光核生产;电子直线加速器;

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1. Accelerator-based photoproduction of promising beta-emitters Cu-67 and Sc-47 [J] . Starovoitova Valeriia N., Cole Philip L., Grimm Terry L. Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry . 2015,第1期

机译：基于加速剂的有希望的β-发射体Cu-67和Sc-47的照相生产
2. Calculation of productions of medical Pb-201, Au-198, Re-186, Ag-111, (103)pd, Y-90, Sr-89, Kr-77, Cu-77, Cu-67, Cu-64, Sc-47 and P-32 nuclei used in cancer therapy via phenomenological and microscopic level density models [J] . Artun Ozan Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2019,第期

机译：用医疗PB-201，AU-198，RE-186，AG-111，（103）Pd，Y-90，SR-89，KR-77，Cu-77，Cu-67，Cu-64的制造的计算 SC-47和P-32核，通过现象学和微观水平密度模型用于癌症治疗
3. Production of Cu-67 by enriched Zn-70 targets: first measurements of formation cross sections of Cu-67, Cu-64, Ga-67, Ga-66, Zn-69m and Zn-65 in interactions of Zn-70 with protons above 45 MeV [J] . Pupillo Gaia, Mou Liliana, Martini Petra, Radiochimica Acta: International Journal for Chemical Aspects of Nuclear Science and Technology . 2020,第8期

机译：通过富集的Zn-70靶的Cu-67的产生：首先测量Cu-67，Cu-64，Ga-67，Ga-66，Zn-69m和Zn-65的形成横截面，与质子相互作用超过45 mev.
4. LINAC PRODUCTION OF Cu-67: DESIGN, PRODUCTION, AND SEPARATION [C] . David A. Rotsch, David A. Ehst, Nicholas A. Smith, 8th International Conference on Isotopes 2014 . 2014

机译：Cu-67的直线加速器生产：设计，生产和分离
5. Unified models to study multicore scaling limits and accelerator-based solutions [D] . Blem, Emily R. 2013

机译：用于研究多核扩展限制和基于加速器的解决方案的统一模型
6. Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals [O] . Guangru Li, Wei Jiang, Lu Zhang, 2021

机译：基于加速器的BNCT与多终端的光束整形组件的设计
7. Q_EC values of the Superallowed beta-Emitters 10-C, 34-Ar, 38-Ca and 46-V [O] . Eronen, T., Gorelov, D., Hakala, J., 2011

机译：超高温β-Emitters 10-C，34-ar，38-Ca和...的Q_EC值 46-V
8. Purification of Cu-67 and Macrocyclic chelates for targeted therapy. DOE annual report, 1993--94 [R] . DeNardo, S. J. 1994

机译：纯化Cu-67和大环螯合物用于靶向治疗。能源部年度报告，1993--94

Accelerator-based photoproduction of promising beta-emitters Cu-67 and Sc-47

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