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首页> 外文期刊>Journal of separation science. >Analysis of volatile components of drugs and explosives by solid phase microextraction-ion mobility spectrometry
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Analysis of volatile components of drugs and explosives by solid phase microextraction-ion mobility spectrometry

机译：固相微萃取-离子迁移谱法分析毒品和炸药中的挥发性成分

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Current ion mobility spectrometry (IMS) devices are used to detect drugs and explosives in the form of particles and, in cases where the vapor pressure of the drugs or explosives is sufficiently high, the gas can be sampled and detected directly. The aim of this study is to demonstrate the use of solid phase microextraction (SPME) as a preconcentration technique coupled to an IMS for the detection of odor signature compounds of drugs and explosives. The reduced mobilities (K-o) and IMS operating conditions for the odor signature compounds of cocaine, marijuana, and 3,4-methylenedioxy-N-methylamphetamine (MDMA) are reported for the first time. LODs, linear dynamic ranges (LDRs), and the precision of the analysis of these odor signature compounds, and the explosive taggant 2,3-dimethyl-2,3-dinitrobutane (DMNB) were obtained by SPME-IMS and normal INIS conditions. The systematic optimization of the INIS operating parameters for the detection of these odor compounds is also reported incorporating the use of genetic algorithms (GAs) for finding the optimal settings for the detection of these compounds of interest. These results support the case for targeting volatile components as a presumptive detection for the presence of the parent compounds of drugs and explosives. Furthermore, the IMS-specific GA developed can be used as an optimization tool for the detection of other compounds of interest in future work.
机译：当前的离子迁移谱（IMS）设备用于检测颗粒形式的毒品和爆炸物，并且在毒品或爆炸物的蒸气压足够高的情况下，可以直接对气体进行采样和检测。这项研究的目的是证明固相微萃取（SPME）作为与IMS结合使用的预浓缩技术，可用于检测药物和炸药的气味特征化合物。首次报道了可卡因，大麻和3,4-亚甲二氧基-N-甲基苯丙胺（MDMA）的气味特征化合物的降低的迁移率（K-o）和IMS操作条件。通过SPME-IMS和正常的INIS条件获得了LOD，线性动态范围（LDR）和这些气味特征化合物以及爆炸性标记剂2,3-二甲基-2,3-二硝基丁烷（DMNB）的分析精度。还报告了结合使用遗传算法（GA）来寻找用于检测这些目标化合物的最佳设置的INIS操作参数的系统优化，以检测这些气味化合物。这些结果支持了以挥发性成分为目标的情况，作为对毒品和爆炸物母体化合物存在的推测检测。此外，开发的IMS专用GA可用作优化工具，用于检测未来工作中其他感兴趣的化合物。

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