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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Inhibition of the DHT-induced PSA secretion by Verbascum xanthophoeniceum and Serenoa repens extracts in human LNCaP prostate epithelial cells
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Inhibition of the DHT-induced PSA secretion by Verbascum xanthophoeniceum and Serenoa repens extracts in human LNCaP prostate epithelial cells

机译：狼尾草和毛叶芹提取物对人LNCaP前列腺上皮细胞中DHT诱导的PSA分泌的抑制

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摘要

Ethnopharmacological relevance Verbascum xanthophoeniceum is a mullein plant, typical of Balkan region and some parts of Turkey, traditionally used as phytotherapeutic agent due to its anti-inflammatory properties. It is rich in phenylethanoid and iridoid metabolites whose anti-inflammatory properties are under characterization. Materials and methods The role of Verbascum xanthophoeniceum crude methanolic extract and its isolated phenylethanoid glycoside verbascoside have been evaluated, in comparison to a saw palmetto extract, on a human in vitro model of androgen-regulated prostate epithelium, the LNCaP cell line. Cytotoxicity and DHT-induced free and total PSA secretion have been thoroughly studied. Results We have found that similar to saw palmetto, Verbascum xanthophoeniceum extract and its isolated phenylethanoid glycoside verbascoside have no cytotoxicity in human LNCaP prostate epithelial cells, whereas an inhibitory effect on the DHT-induced free and total PSA secretion, a recognized anti-androgen like activity, has been shown in case of both Verbascum xanthophoeniceum extract and pure verbascoside. Furthermore, in the absence of the endogenous androgen DHT, an androgen-like activity in Verbascum xanthophoeniceum is detectable as it is for saw palmetto, suggesting that a mixed androgen-antiandrogen activity is present. Conclusions For the first time, Serenoa repens and Verbascum xanthophoeniceum extracts have shown an absence of cytotoxicity and an inhibitory effect on DHT-induced PSA secretion in an in vitro model of human prostate epithelium, whereas the phenylethanoid glycoside verbascoside appeared to explain only part of the Verbascum xanthophoeniceum inhibitory activity on PSA secretion.
机译：民族药理相关性Verbascum xanthophoeniceum是毛蕊花植物，是巴尔干地区和土耳其某些地区的典型植物，由于其抗炎特性，通常用作植物治疗剂。它富含其消炎特性尚在表征中的苯乙类固醇和铱化合物。材料和方法与锯棕榈提取物相比，在雄激素调节的前列腺上皮人LNCaP细胞系体外模型中，已评估了草绿油菜粗品甲醇提取物及其分离的苯乙酮类糖苷Verbascoside的作用。细胞毒性和DHT诱导的游离PSA和总PSA分泌已被彻底研究。结果我们发现，与锯棕榈相似，马鞭草黄腐菊提取物及其分离的苯乙醇类苷马鞭草苷对人LNCaP前列腺上皮细胞无细胞毒性，而对DHT诱导的游离和总PSA分泌具有抑制作用，是公认的抗雄激素样物质。凡士林黄腐菊提取物和纯马齿co苷均具有活性。此外，在缺乏内源性雄激素DHT的情况下，在锯木黄蜂中可以检测到雄激素样活性，就像锯棕榈一样，这表明存在混合的雄激素-雄激素活性。结论Serenoa repens和Verbascum xanthophoeniceum提取物首次在人前列腺上皮细胞体外模型中显示出无细胞毒性和对DHT诱导的PSA分泌的抑制作用，而苯乙酮类糖苷马齿bas苷似乎只能解释部分原因。毛黄蜂对PSA分泌的抑制活性。

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