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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Diuretic and nephroprotective effect of Jawarish Zarooni Sada--a polyherbal unani formulation.
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Diuretic and nephroprotective effect of Jawarish Zarooni Sada--a polyherbal unani formulation.

机译：Jawarish Zarooni Sada的利尿和肾保护作用-多草药Unani制剂。

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摘要

A number of drugs, both single and compound preparations are used widely in Tibb-e-Unani (Unani medicine) in the management of renal diseases. But such drugs mostly, have not been investigated for their described effects. Jawarish Zarooni Sada (JZS) is one such polyherbal preparation containing 15 ingredients, mainly described to be diuretic and nephroprotective. Therefore, in the present study ethanol and water extracts of JZS (300 mg each) were investigated for diuretic activity by measuring the total urine output over a period of 6h. Sodium and potassium level in urine sample was also estimated. Nephroprotective activity of JZS against gentamicin-induced nephrotoxicity was investigated by administering JZS along with high dose of gentamicin (40 mg/kg) and elevation of serum urea and serum creatinine was taken as the index of nephrotoxicity. JZS showed significant diuretic and nephroprotective effect.
机译：Tibb-e-Unani（Unani药物）中广泛使用多种药物（单一制剂和复合制剂）来治疗肾脏疾病。但是这类药物大多尚未描述其作用。 Jawarish Zarooni Sada（JZS）是一种这样的多草药制剂，包含15种成分，主要被描述为利尿剂和肾保护剂。因此，在本研究中，通过测量6h期间的总尿量，研究了JZS乙醇和水提取物（每种300 mg）的利尿活性。还估算了尿液样本中的钠和钾水平。通过与高剂量庆大霉素（40 mg / kg）一起服用JZS来研究JZS对庆大霉素诱导的肾毒性的肾保护活性，并将血清尿素和血清肌酐的升高作为肾毒性的指标。 JZS具有明显的利尿和肾保护作用。

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