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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy.
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Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy.

机译：低频重复经颅磁刺激治疗难治性部分性癫痫。

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Seventeen refractory partial epilepsy patients were enrolled in an open-label study to evaluate the antiepileptic effect of low-frequency repetitive transcranial magnetic stimulation (rTMS). Seven of the patients had not obtained seizure-free status after epileptogenic focus resection surgery before they were enrolled in the study. All patients were treated with low-frequency rTMS which included 3 sessions per day (0.5 Hz, 90% RMT and 500 pulses each session) and lasted for 2 weeks. Seizure frequency, seizure days and epileptic discharges in the EEG obtained before, during and after stimulation were compared. The psychological conditions of all individual patients were evaluated with Symptom Checklist-90 (SCL-90) before and after rTMS treatment. Mean seizure frequencies per week significantly decreased in the following 4-week rTMS treatment period compared with the pretreatment period (14.09 vs. 5.63, p < 0.05, mean reduction of 60.02% in seizure frequency). Mean seizure days per week during the treatment period and the post-treatment period were lower than that of the pretreatment period (5.18 vs. 2.99 p < 0.05, mean reduction of 42.5% in seizure days). Mean epileptic discharges in the EEG decreased significantly during the treatment period compared to that of the pre-treatment period (78.60 vs. 66.09, p < 0.05, mean reduction of 15.9% in epileptic spikes discharges) in all 17 patients. Fourteen patients completed the test of Symptom Checklist-90 effectively. The scales of Global Severity Index, Depression, Anxiety, Phobic anxiety, Paranoid ideation, Psychoticism, Somatization, Obsession-compulsion, Interpersonal sensitivity, Hostility in patients decreased respectively at the post-treatment periods compared with those of the pre-treatment periods (P < 0.05). Low-frequency rTMS may have a significant antiepileptic effect in patients with refractory partial epilepsy. Additionally, our results indicate rTMS treatment can improve the psychological condition of these patients.
机译：17名难治性部分性癫痫患者参加了一项开放性研究，以评估低频重复经颅磁刺激（rTMS）的抗癫痫作用。七名患者在被纳入研究前，未在癫痫病灶切除手术后获得无癫痫状态。所有患者均接受了低频rTMS治疗，包括每天3个疗程（0.5 Hz，90％RMT和每个疗程500个脉冲），持续2周。比较了刺激前后，发作前后的癫痫发作频率，发作天数和癫痫放电。在rTMS治疗之前和之后，使用Symptom Checklist-90（SCL-90）对所有患者的心理状况进行评估。与治疗前相比，在接下来的4周rTMS治疗期间，每周平均癫痫发作频率显着降低（14.09 vs. 5.63，p <0.05，癫痫发作频率平均降低60.02％）。在治疗期间和治疗后期间，每周平均癫痫发作天数低于治疗前时期（5.18比2.99 p <0.05，癫痫发作天平均减少42.5％）。在治疗期间，所有17例患者的脑电图平均癫痫放电均较治疗前明显降低（78.60比66.09，p <0.05，癫痫峰值放电平均降低15.9％）。 14名患者有效地完成了症状清单90的测试。与治疗前相比，治疗后患者的全球严重程度指数，抑郁，焦虑，恐惧性焦虑，偏执观念，精神病，躯体化，强迫症，人际关系敏感度，敌对程度分别降低（P <0.05）。低频rTMS对难治性部分性癫痫患者可能具有显着的抗癫痫作用。此外，我们的结果表明，rTMS治疗可以改善这些患者的心理状况。

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