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首页> 外文期刊>Clinical drug investigation >Pantoprazole: a proton pump inhibitor.
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Pantoprazole: a proton pump inhibitor.

机译:top托拉唑:质子泵抑制剂。

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Pantoprazole is a proton pump inhibitor (PPI) that binds irreversibly and specifically to the proton pump, thereby reducing gastric acid secretion. Pantoprazole has a relatively long duration of action compared with other PPIs, and a lower propensity to become activated in slightly acidic body compartments. To date, no drug-drug interactions have been identified with pantoprazole in numerous interaction studies. Overall, in the short-term (8-10 weeks) initial treatment of gastro-oesophageal reflux disease (a condition that occurs when the reflux of gastric contents causes troublesome symptoms and/or complications) and long-term (6-24 months) maintenance therapy, oral pantoprazole 20 or 40 mg/day demonstrated similar efficacy to omeprazole, lansoprazole and esomeprazole and greater efficacy than histamine type 2 receptor antagonists. Pantoprazole is also effective in treating and preventing NSAID-related gastric and gastroduodenal injury. The optimal adult oral dose for gastric acid-related disorders is pantoprazole 40 mg once daily. Although data are limited, pantoprazole 20 or 40 mg/day was effective and well tolerated in the treatment of acid-related disorders in children and adolescents. Pantoprazole was also well tolerated in adults with acid-related disorders in short- and long-term studies. Thus, pantoprazole is a valuable agent for the management of acid-related disorders.
机译:top托拉唑是质子泵抑制剂(PPI),不可逆地且特异性地与质子泵结合,从而减少了胃酸的分泌。与其他PPI相比,托拉唑的作用持续时间相对较长,并且在微酸性体腔中被活化的可能性较低。迄今为止,在许多相互作用研究中,尚未确定与pan托拉唑发生药物-药物相互作用。总体而言,在短期(8-10周)的胃食管反流病(当胃内容物反流引起麻烦的症状和/或并发症时发生的疾病)的初始治疗和长期(6-24个月)维持治疗后,口服20或40 mg /天的潘托拉唑显示出与奥美拉唑,兰索拉唑和埃索美拉唑相似的疗效,并且比组胺2型受体拮抗剂的疗效更高。 top托拉唑还可以有效治疗和预防NSAID相关的胃和胃十二指肠损伤。成人胃酸相关疾病的最佳口服剂量是pan托拉唑40 mg,每天一次。尽管数据有限,但潘托拉唑20或40毫克/天对儿童和青少年与酸有关的疾病有效且耐受性良好。在短期和长期研究中,患有酸相关疾病的成年人对潘托拉唑的耐受性也很好。因此,pan托拉唑是治疗酸相关疾病的有价值的药物。

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