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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis.
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Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis.

机译：偏头痛患者的血管危险因素，内皮功能和颈动脉厚度：与动脉粥样硬化的关系。

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Recent studies indicated that migraine is associated with specific vascular risk profile. However, the functional and structural vascular abnormalities in migraine are rarely addressed. We evaluated the vascular risk factors, endothelial function, and carotid artery (CA)-intima-media thickness (IMT), segregators of preclinical atherosclerosis, in migraineurs. This preliminary study included 63 adults with headache (migraine with aura [n=14], migraine without aura [n=24], transformed migraine [n=6], and tension headache [n=19]) and 35 matched healthy subjects. The following vascular risks were assessed: body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressures (DBP), serum levels of C-reactive protein, fasting glucose, fasting insulin, total cholesterol, and triglycerides. Plasma endothelin (ET)-1, a vasoactive peptide produced by vascular smooth muscle cells and marker for endothelial injury and atherosclerosis, was measured. Endothelial-dependent vasoreactivity was assessed using brachial artery flow-mediated dilatation (FMD) in response to hyperemia. CA-IMT, structural marker of early atherosclerosis, was measured. Compared with control subjects, SBP, DBP, glucose, insulin, ET-1, and CA-IMT were elevated with migraine. FMD% was inversely correlated with SBP (P < .001), DBP (P < .01), glucose (P < .001), and insulin levels (P < .01). CA-IMT was correlated with BMI (P < .05), SBP (P < .01), total cholesterol (P < .01), triglycerides (P < .001), glucose (P < .001), insulin (P < .01), and FMD% (P < .05). In multivariate analysis, ET-1 was correlated with duration of illness, SBP, DBP, glucose, insulin, IMT, and FMD%. We conclude that endothelial injury, impaired endothelial vasoreactivity, and increased CA-IMT occur with migraine and are associated with vascular risk factors that strongly suggest that migraine could be a risk for atherosclerosis.
机译：最近的研究表明，偏头痛与特定的血管风险状况有关。但是，偏头痛的功能性和结构性血管异常很少得到解决。我们评估了偏头痛患者的血管危险因素，内皮功能和颈动脉（CA）-内膜中膜厚度（IMT），临床前动脉粥样硬化的隔离物。这项初步研究包括63位成人头痛（有先兆偏头痛[n = 14]，无先兆偏头痛[n = 24]，转化性偏头痛[n = 6]和紧张性头痛[n = 19]）和35名健康受试者。评估了以下血管风险：体重指数（BMI），收缩压（SBP）和舒张压（DBP），C反应蛋白的血清水平，空腹血糖，空腹胰岛素，总胆固醇和甘油三酸酯。测量了血浆内皮素（ET）-1，它是由血管平滑肌细胞产生的血管活性肽和内皮损伤和动脉粥样硬化的标志物。血管内皮依赖性血管反应性评估使用肱动脉血流介导的扩张（FMD）来应对充血。测量了CA-IMT，早期动脉粥样硬化的结构标志。与对照组相比，偏头痛可使SBP，DBP，葡萄糖，胰岛素，ET-1和CA-IMT升高。 FMD％与SBP（P <.001），DBP（P <.01），葡萄糖（P <.001）和胰岛素水平（P <.01）成反比。 CA-IMT与BMI（P <.05），SBP（P <.01），总胆固醇（P <.01），甘油三酸酯（P <.001），葡萄糖（P <.001），胰岛素（P <.01）和FMD％（P <.05）。在多变量分析中，ET-1与病程，SBP，DBP，葡萄糖，胰岛素，IMT和FMD％相关。我们得出结论，偏头痛会发生内皮损伤，内皮血管反应性受损和CA-IMT升高，并且与血管危险因素相关，这些因素强烈表明偏头痛可能是动脉粥样硬化的风险。

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