Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

Li Jingwei; Chen Yan; Zhang Xin; Zhang Bing; Zhang Meijuan; Xu Yun

首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

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Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

机译：人尿中的Kallidinogenase可通过缩短磁共振成像的平均通过时间来改善中风患者的预后

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Background: Improving cerebral perfusion remains a good option for ischemic stroke for restoring cerebral blood flow. Human urinary kallidinogenase has been shown promising in treating stroke patients. To investigate whether human urinary kallidinogenase's efficacy in treating stroke patients has relationship with improving cerebral perfusion and possible mechanism. Methods: Fifty-eight stroke patients in Nanjing Drum Tower Hospital were enrolled in this prospective study. Of them, 29 received human urinary kallidinogenase, while the other 29 were selected as control. National institute health stroke scale, modified Rankin Scale and activities of daily living score were used to determine patient outcome. Cerebral perfusion in patients was determined by perfusion magnetic resonance imaging. Serum apelin and vascular endothelial growth factor were measured by enzyme-linked immunosorbent assay. Results: We confirmed that human urinary kallidinogenase improved stroke outcome in patients. Cerebral perfusion was elevated by human urinary kallidinogenase 12 days after therapy. Human urinary kallidinogenase enhanced vascular endothelial growth factor and APJ expression in stroke patients. The reduced mean transit time was related with favorable outcome analyzed by univariate logistic regression. Conclusions: Human urinary kallidinogenase facilitated stroke recovery and enhanced cerebral reperfusion through up-regulating vascular endothelial growth factor, apelin/APJ pathway.

机译：背景：改善脑灌注仍然是缺血性中风恢复脑血流的一个很好的选择。已经显示人尿激肽原酶在治疗中风患者中很有希望。目的探讨人尿中降钙素原酶在治疗中风患者中的功效是否与改善脑灌注和可能的机制有关。方法：本研究纳入了南京鼓楼医院的58例中风患者。其中，有29人接受了人尿中的尿激肽原酶，而其他29人被选为对照。美国国家卫生研究院健康卒中量表，改良的兰金量表和日常生活活动量表用于确定患者的预后。通过灌注磁共振成像确定患者的脑灌注。用酶联免疫吸附法测定血清apelin和血管内皮生长因子。结果：我们证实人尿中的尿激肽原酶可改善患者的中风预后。治疗后12天，人尿中的kallidinogenase增加了脑灌注。人尿中激肽原酶在中风患者中增强了血管内皮生长因子和APJ的表达。通过单因素逻辑回归分析，平均运输时间的减少与良好的结果相关。结论：人尿中激肽原酶通过上调血管内皮生长因子，apelin / APJ途径促进中风恢复并增强脑再灌注。

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《Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association》 |2015年第8期|共8页
作者
Li Jingwei; Chen Yan; Zhang Xin; Zhang Bing; Zhang Meijuan; Xu Yun;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Human urinary kallidinogenase; ischemic stroke; cerebral perfusion; angiogenesis; VEGF; apelin/APJ;

机译：人尿激肽原酶;缺血性中风;脑灌注;血管生成;VEGF;apelin / APJ;

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1. Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging [J] . Li Jingwei, Chen Yan, Zhang Xin, Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association . 2015,第8期

机译：人尿中的Kallidinogenase可通过缩短磁共振成像的平均通过时间来改善中风患者的预后
2. Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months [J] . Xuezhu Song, Lixin Han, Yan Liu 中国神经再生研究（英文版） . 2012,第011期

机译：人尿醛缩酶原酶后6个月后急性脑梗死患者运动皮质功能的重塑
3. Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. [J] . Kane I, Carpenter T, Chappell F, Stroke: A Journal of Cerebral Circulation . 2007,第12期

机译：急性缺血性卒中的10种不同磁共振灌注成像处理方法的比较：对病变大小，弥散/灌注不匹配患者比例，临床评分和影像学结果的影响。
4. Automated prediction of tissue outcome after acute ischemic stroke in Computed Tomography perfusion images [C] . Pieter C. Vos, Edwin Bennink, Hugo de Jong, Conference on computer-aided diagnosis . 2015

机译：在计算机断层扫描灌注图像中自动预测急性缺血性中风后的组织结局
5. Time-resolved contrast-enhanced coronary magnetic resonance angiography and myocardial perfusion magnetic resonance imaging with highly constrained back projection. [D] . Ge, Lan. 2010

机译：时间分辨对比增强的冠状动脉磁共振血管造影和心肌灌注磁共振成像，高度受限的背投影。
6. Human Urinary Kallidinogenase Promotes Angiogenesis and Cerebral Perfusion in Experimental Stroke [O] . Lijuan Han, Jie Li, Yanting Chen, -1

机译：人尿中的Kallidinogenase促进实验性中风的血管生成和脑灌注
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Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

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