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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Clinical Study of Lacunar Infarcts in Non-hypertensive Patients
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Clinical Study of Lacunar Infarcts in Non-hypertensive Patients

机译：非高血压患者腔隙性脑梗死的临床研究

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摘要

Lacunar infarcts in non-hypertensive patients have been scantly assessed. The objective of this study was to determine clinical features of lacunar infarct in patients without hypertension (n = 91) in comparison with characteristics of lacunar infarcts occurring in patients with hypertension (n = 283) collected from a prospective hospital-based stroke registry in which 2000 patients with acute stroke are included. Predictors of lacunar infarct in patients without hypertension were assessed by multiple logistic regression analysis. The group of non-hypertensive patients with lacunar infarction showed a significantly higher frequency of male gender, age 85 years or older, history of atrial fibrillation, chronic obstructive pulmonary disease and diabetes mellitus, and a significantly lower frequency of female gender and absence of limitation at hospital discharge than hypertensive patients with lacunar infarct. Differences between hypertensive and non-hypertensive patients in relation to frequency of the different lacunar syndromes were not observed. After multivariate analysis, age 85 years or older (odds ratio 3.13), diabetes (odds ratio 2.57), and male gender (odds ratio 1.99) seemed to be independent factors associated with lacunar infarct in patients without hypertension. Lacunar infarct in non-hypertensive patients showed some differential clinical features compared to the remaining lacunar infarctions because it occurred more frequently in male patients aged 85 years or older, In this group, diabetes was the most important modificable risk factor. These results suggest an ealier effect of arteriopathy caused by hypertension favoring lacunar brain ischemia, whereas in non-hypertensive patients, arteropathy responsible for small vessel disease would take a more prolonged time in causing lacunar infarction.
机译：对非高血压患者的腔隙性梗塞进行了评估。这项研究的目的是，与从前瞻性医院卒中登记处收集的高血压患者（n = 283）发生的腔隙性梗死特征进行比较，以确定无高血压患者的腔隙性梗死的临床特征。包括2000例急性中风患者。无高血压患者的腔隙性梗塞的预测因素通过多元逻辑回归分析进行评估。非高血压腔隙性脑梗死患者组中，男性，85岁或85岁以上男性的发病率显着较高，有心房颤动，慢性阻塞性肺疾病和糖尿病的病史，女性性别的发病率显着较低且没有限制出院时比高血压患者有腔隙性梗塞。未观察到高血压患者和非高血压患者之间因腔隙综合征的发生频率而产生的差异。经过多因素分析后，在没有高血压的患者中，年龄大于等于85岁（比值比3.13），糖尿病（比值比2.57）和男性（比值比1.99）是与腔隙性梗塞相关的独立因素。与其余的腔隙性梗塞相比，非高血压患者的腔隙性梗塞表现出一些不同的临床特征，因为它在85岁或以上的男性患者中更常见。在这一组中，糖尿病是最重要的可改变的危险因素。这些结果表明由高血压引起的动脉病变具有更明显的效果，有利于腔隙性脑缺血，而在非高血压患者中，负责小血管疾病的动脉病变将导致更长的时间导致腔隙性脑梗塞。

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