...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Activity of Malignancy May Determine Stroke Pattern in Cancer Patients
【24h】

The Activity of Malignancy May Determine Stroke Pattern in Cancer Patients

机译：恶性活动可能决定癌症患者的中风模式

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: It has been suggested that stroke in patients with cancer may differ from the conventional pattern. The aim of this study was to evaluate the burden of vascular risk factors, stroke etiology, and short-term outcome in patients with active and nonactive malignancy compared with patients without cancer. Methods: This is a prospective cohort study of consecutive acute stroke patients admitted to our department between September 2006 and September 2011. We distinguished between the following: (1) patients with active malignancy (AM, diagnosed not earlier than 12 months before stroke); (2) patients with nonactive malignancy (non-AM); and (3) cancer-free (CF) patients, used as a reference. Results: Pre-existing cancer was found in 90 of 1558 patients, including 41 (2.6%) cases with AM and 49 (3.1%) cases with non-AM. Compared with CF patients, AM patients less frequently had a history of previous stroke (2.4% versus 17.9%, P = .018) and more frequently experienced ischemic strokes of undetermined etiology (62.5% versus 38.3%, P = .002). Non-AM patients did not differ in the distribution of vascular risk factors but more often experienced stroke caused by small vessel occlusion (20.0% versus 8.0%, P = .004). Inflammatory blood markers were elevated especially in patients with AM. Short-term prognosis was similar across all groups. Conclusions: Stroke pattern in patients with non-AM appears very similar to that observed in the CF patients. However, our findings support the thesis that cancer-specific prothrombotic mechanisms play an important role in stroke patients with AM, which may be related to active inflammatory and immune processes. Malignancy does not influence short-term prognosis of stroke.
机译：背景：已经提出，癌症患者的中风可能与传统模式不同。这项研究的目的是评估活动性和非活动性恶性肿瘤患者与没有癌症的患者相比，其血管危险因素，中风病因和短期预后的负担。方法：这是一项对2006年9月至2011年9月间入院的连续性急性卒中患者进行的前瞻性队列研究。 （2）非活动性恶性肿瘤（non-AM）的患者; （3）无癌（CF）患者，用作参考。结果：1558例患者中有90例存在癌症，其中41例（2.6％）患有AM和49例（3.1％）患有非AM。与CF患者相比，AM患者先前有中风史的患者较少（2.4％对17.9％，P = .018），病因未明的缺血性脑卒中的发生频率较高（62.5％对38.3％，P = .002）。非AM患者的血管危险因素分布没有差异，但因小血管阻塞引起的卒中发生率更高（20.0％对8.0％，P = .004）。炎性血液标志物升高，尤其是在AM患者中。所有组的短期预后相似。结论：非AM患者的卒中模式似乎与CF患者相似。然而，我们的发现支持以下论点：特定于癌症的血栓形成机制在中风性AM患者中起重要作用，这可能与活跃的炎症和免疫过程有关。恶性肿瘤不会影响中风的短期预后。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号