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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cognitive Correlates of Cerebral Vasoreactivity on Transcranial Doppler in Older Adults
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Cognitive Correlates of Cerebral Vasoreactivity on Transcranial Doppler in Older Adults

机译：老年人经颅多普勒对脑血管反应性的认知相关性

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Background: This study was performed to explore the possible contributions of cerebral hemodynamic changes to the cognitive impairment in patients with Alzheimer's disease (AD). Methods: A total of 194 participants were included: 52 controls, 75 patients with mild cognitive impairment (MCI), and 67 patients with AD. Demographic characteristics, vascular risks, mini-mental state examination MMSE), and clinical dementia rating (CDR) were assessed, and magnetic resonance imaging of the brain was performed to evaluate white matter hyperintensities (WMHs). Using transcranial Doppler (TCD) ultrasonography, cerebrovascular reactivity (CVR) was evaluated with a breath-holding test, in addition to the mean blood flow velocity (MFV), pulsatility index (PI), and resistance index (RI) of the middle cerebral artery. Results: After adjusting for covariates such as age, education, WMH severity, and vascular risks, TCD parameters such as MFV, PI, and RI did not differ between the 3 groups. However, CVR was significantly reduced in the AD group (45.33 +/- 11.49%), compared with the other groups (56.36 +/- 14.65%, controls; 53.84 +/- 15.47%, MCI group; P < .001). Multiple regression analyses also showed that CVR was associated with MMSE scores. CVR differed according to the CDR scores (P < .001). Conclusions: Our finding may be suggestive of an underlying microangiopathic mechanism in AD patients. Furthermore, there was an association between the impaired function of cerebral microvessels and cognitive impairment. Further research is needed to fully establish whether altered cerebral hemodynamics may be considered an independent factor in predicting cognitive decline or an effect of pathologic processes involved in AD.
机译：背景：本研究旨在探讨阿尔茨海默氏病（AD）患者脑血流动力学变化对认知障碍的可能贡献。方法：总共包括194名参与者：52名对照，75名轻度认知障碍（MCI）患者和67名AD患者。人口统计学特征，血管风险，迷你精神状态检查（MMSE）和临床痴呆评分（CDR）进行了评估，并进行了大脑的磁共振成像以评估白质高强度（WMH）。使用经颅多普勒（TCD）超声检查，通过屏气试验评估了脑血管反应性（CVR），此外还评估了中脑的平均血流速度（MFV），搏动指数（PI）和阻力指数（RI）动脉。结果：调整了年龄，教育程度，WMH严重程度和血管风险等协变量后，三组之间的TCD参数（如MFV，PI和RI）没有差异。然而，与其他组（对照组为56.36 +/- 14.65％;对照组; MCI组为53.84 +/- 15.47％; P <.001）相比，AD组的CVR显着降低（45.33 +/- 11.49％）。多元回归分析还显示，CVR与MMSE得分相关。 CVR因CDR分数而异（P <.001）。结论：我们的发现可能提示AD患者潜在的微血管病变机制。此外，脑微血管功能受损与认知障碍之间存在关联。需要进一步的研究来完全确定改变的脑血流动力学是否可以被认为是预测认知下降或AD涉及的病理过程影响的独立因素。

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