• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Borax Partially Prevents Neurologic Disability and Oxidative Stress in Experimental Spinal Cord Ischemia/Reperfusion Injury
【24h】

Borax Partially Prevents Neurologic Disability and Oxidative Stress in Experimental Spinal Cord Ischemia/Reperfusion Injury

机译：硼砂可部分预防实验性脊髓缺血/再灌注损伤中的神经功能障碍和氧化应激

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: The aim of this study is to investigate the potential effects of borax on ischemia/reperfusion injury of the rat spinal cord. Methods: Twenty-one Wistar albino rats were divided into 3 groups: sham (no ischemia/reperfusion), ischemia/reperfusion, and borax (ischemia/reperfusion + borax); each group was consist of 7 animals. Infrarenal aortic cross clamp was applied for 30 minutes to generate spinal cord ischemia. Animals were evaluated functionally with the Basso, Beattie, and Bresnahan scoring system and inclined-plane test. The spinal cord tissue samples were harvested to analyze tissue concentrations of nitric oxide, nitric oxide synthase activity, xanthine oxidase activity, total antioxidant capacity, and total oxidant status and to perform histopathological examination. Results: At the 72nd hour after ischemia, the borax group had significantly higher Basso, Beattie, and Bresnahan and inclined-plane scores than those of ischemia/reperfusion group. Histopathological examination of spinal cord tissues in borax group showed that treatment with borax significantly reduced the degree of spinal cord edema, inflammation, and tissue injury disclosed by light microscopy. Xanthine oxidase activity and total oxidant status levels of the ischemia/reperfusion group were significantly higher than those of the sham and borax groups (P >.05), and total antioxidant capacity levels of borax group were significantly higher than those of the ischemia/reperfusion group (P > .05). There was not a significantly difference between the sham and borax groups in terms of total antioxidant capacity levels (P > .05). The nitric oxide levels and nitric oxide synthase activity of all groups were similar (P >.05). Conclusions: Borax treatment seems to protect the spinal cord against injury in a rat ischemia/reperfusion model and improve neurological outcome.
机译：目的：本研究的目的是研究硼砂对大鼠脊髓缺血/再灌注损伤的潜在影响。方法：Wistar白化病大鼠21只，分为假手术（无缺血/再灌注），缺血/再灌注和硼砂（缺血/再灌注+硼砂）3组。每组由7只动物组成。肾下主动脉夹钳应用30分钟以产生脊髓缺血。使用Basso，Beattie和Bresnahan评分系统和斜面测试对动物进行功能评估。收集脊髓组织样品以分析一氧化氮的组织浓度，一氧化氮合酶活性，黄嘌呤氧化酶活性，总抗氧化剂能力和总氧化剂状态，并进行组织病理学检查。结果：在缺血后第72小时，硼砂组的Basso，Beattie和Bresnahan和斜面评分明显高于缺血/再灌注组。硼砂组脊髓组织的组织病理学检查显示，硼砂治疗可显着降低光学显微镜显示的脊髓水肿，炎症和组织损伤程度。缺血/再灌注组的黄嘌呤氧化酶活性和总氧化剂状态水平显着高于假和硼砂组（P> .05），硼砂组的总抗氧化能力水平显着高于缺血/再灌注组组（P> .05）。假手术组和硼砂治疗组之间在总抗氧化剂能力水平上没有显着差异（P> .05）。所有组的一氧化氮水平和一氧化氮合酶活性相似（P> .05）。结论：硼砂治疗似乎可以保护脊髓免受大鼠缺血/再灌注损伤，并改善神经系统预后。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号