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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Repetitive Transcranial Magnetic Stimulation for Depression Due to Cerebrovascular Disease: A Systematic Review
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Repetitive Transcranial Magnetic Stimulation for Depression Due to Cerebrovascular Disease: A Systematic Review

机译：重复经颅磁刺激对脑血管疾病引起的抑郁症的系统评价

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摘要

Objective: This study aims to perform a systematic review evaluating the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in improving depression resulting from cerebrovascular disease including vascular depression (VD) and poststroke depression (PSD). Methods: A literature search of multiple scientific databases was conducted for English studies published from January 1980 to June 2016. Studies were included if the sample consisted of 50% or more adult humans with VD or PSD and had 3 or more subjects, the intervention applied was rTMS, and depression was assessed pre- and post intervention using a formal outcome measure. Randomized controlled trials (RCTs) were assessed for methodological quality using the Physiotherapy Evidence Database (PEDro) tool. A level of evidence was assigned to each study according to the modified Sackett Scale. Results: Five studies met the inclusion criteria including 3 RCTs (level 1b; PEDro range: 6-8) and 2 uncontrolled pre-post studies (level 4). There were 186 participants with either PSD (n = 40) or VD (n = 146); the majority of the participants were female (52.7%) and had a mean age ranging from 51.9 to 67.9 years. There were no adverse effects reported by any of the studies. Using clinically accepted criteria for the response rate, all studies reported a benefit from rTMS for the treatment of depression. Three studies also demonstrated a benefit on remission rates as well. Conclusions: rTMS was reported to be beneficial in treating depression among individuals with cerebrovascular disease over the short term. However, heterogeneous populations and variability in study design and protocol, as well as a limited number of studies to review, challenge the ability to form conclusions as to the effectiveness of rTMS. (C) 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
机译：目的：本研究旨在进行系统评价，评估重复经颅磁刺激（rTMS）在改善由脑血管疾病（包括血管性抑郁（VD）和中风后抑郁（PSD））引起的抑郁中的有效性。方法：对1980年1月至2016年6月发表的英语研究进行了多个科学数据库的文献检索。如果样本包含50％或以上具有VD或PSD的成年人且有3个或更多受试者，则包括该研究。为rTMS，并使用正式的结局指标对干预前后的抑郁进行评估。使用物理疗法证据数据库（PEDro）工具评估随机对照试验（RCT）的方法学质量。根据修改后的Sackett量表为每个研究分配了一定程度的证据。结果：5项研究符合纳入标准，包括3项RCT（1b级; PEDro范围：6-8）和2项未经控制的事前研究（4级）。有186名PSD（n = 40）或VD（n = 146）的参与者;大多数参与者为女性（52.7％），平均年龄为51.9至67.9岁。任何研究均未报告不良反应。使用临床公认的缓解率标准，所有研究均报告说rTMS可治疗抑郁症。三项研究也显示了对缓解率的益处。结论：据报道，rTMS在短期内可有效治疗脑血管疾病患者的抑郁症。但是，研究设计和方案中的异类种群和变异性以及有限的要审查的研究数量，对就rTMS的有效性得出结论的能力提出了挑战。 （C）2016年全国中风协会。由Elsevier Inc.出版。保留所有权利。

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