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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Early neurologic improvement based on the national institutes of health stroke scale score predicts favorable outcome within 30 minutes after undergoing intravenous recombinant tissue plasminogen activator therapy
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Early neurologic improvement based on the national institutes of health stroke scale score predicts favorable outcome within 30 minutes after undergoing intravenous recombinant tissue plasminogen activator therapy

机译：根据美国国立卫生研究院卒中量表评分的早期神经功能改善，在接受静脉内重组组织纤溶酶原激活剂治疗后30分钟内预示良好结果

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Background: The aim of the present study was to evaluate whether early neurologic improvement (within 30 minutes), as measured using the National Institutes of Health Stroke Scale (NIHSS) score, predicts favorable outcome at 90 days. Methods: Consecutive acute ischemic stroke patients treated with intravenous recombinant tissue plasminogen activator (IV rt-PA) within 3 hours poststroke between March 2006 and September 2011 were analyzed retrospectively. The association between early neurologic improvement based on the NIHSS score (an improvement of ≥3 points at 15 minutes and ≥5 points at 30 minutes) and favorable outcome at 90 days was examined. A favorable outcome was defined as a modified Rankin scale (mRS) score of 0 or 1 at 90 days after treatment. Results: On examination of the time course of the NIHSS score in patients with an improvement of ≥8 points or a score of 0 on the NIHSS after 24 hours, the NIHSS score improved significantly from 15 minutes after IV rt-PA treatment (P =.042) and at 30 minutes (P =.014). On logistic regression analysis, an improvement of ≥3 NIHSS points at 15 minutes (odds ratio [OR] 6.78; 95% confidence interval [CI] 1.72-26.70; P =.006) and an improvement of ≥5 NIHSS points at 30 minutes (OR 4.83; 95% CI 1.05-22.28; P =.043) were associated with a favorable outcome. Conclusions: An improvement of at least 3 points in the NIHSS score at 15 minutes or of at least 5 points at 30 minutes appears to be a predictor of favorable outcome and helps to identify patients who will not respond to rt-PA therapy.
机译：背景：本研究的目的是评估使用美国国立卫生研究院卒中量表（NIHSS）评分测得的早期神经系统改善（30分钟以内）能否预测90天的良好转归。方法：回顾性分析2006年3月至2011年9月中风后3小时内接受静脉内重组组织纤溶酶原激活剂（IV rt-PA）治疗的急性缺血性中风患者。研究了基于NIHSS评分的早期神经功能改善（15分钟时≥3分，30分钟时≥5分）与90天时良好转归之间的关系。良好的结局定义为治疗后90天的改良兰金评分（mRS）评分为0或1。结果：检查24小时后NIHSS得分≥8分或NIHSS得分为0的患者的NIHSS得分的时程，从静脉rt-PA治疗后15分钟起NIHSS得分显着改善（P = .042）和30分钟（P = .014）。在逻辑回归分析中，在15分钟时改善了≥3个NIHSS点（赔率[OR] 6.78; 95％置信区间[CI] 1.72-26.70; P = .006），在30分钟时改善了≥5NIHSS点（OR 4.83; 95％CI 1.05-22.28; P = .043）与良好的预后相关。结论：NIHSS评分在15分钟时至少改善3分或在30分钟时至少5分改善似乎是预后良好的指标，并有助于确定对rt-PA治疗无反应的患者。

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