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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Simple clinical predictors of stroke outcome based on National Institutes of Health Stroke Scale score during 1-h recombinant tissue-type plasminogen activator infusion
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Simple clinical predictors of stroke outcome based on National Institutes of Health Stroke Scale score during 1-h recombinant tissue-type plasminogen activator infusion

机译：基于国家健康卒中规模分数的中风成果简单的临床预测因子1-H重组组织型纤溶酶原激活剂输注

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Background and purpose: An index for predictors of stroke outcome was determined based on the National Institutes of Health Stroke Scale (NIHSS) scores during 1-h intravenous administration of recombinant tissue-type plasminogen activator (rt-PA). Methods: Stroke patients with baseline NIHSS score ≥8 and occlusion at the internal carotid or middle cerebral arteries (ICA, MCA) were retrospectively studied from a prospective single-center registry. NIHSS scores and inverse change from baseline scores (ΔNIHSS) were assessed at 30 min and 1 h after rt-PA infusion. Patients were divided into two groups according to arterial occlusion sites: group P, ICA or proximal M1; and group D, distal M1 or M2. A modified Rankin Scale score of 2-6 at 3 months was defined as an unfavorable outcome. Results: In all 108 patients, the cutoff NIHSS score predicting unfavorable outcome was ≥12 and cutoff ΔNIHSS scores were ≤2 at both 30 min and 1 h. In group P (n = 36), the cutoff NIHSS score was ≥14 at both 30 min and 1 h and cutoff ΔNIHSS scores were ≤1 at 30 min and ≤2 at 1 h. Unfavorable outcome was seen in all patients with NIHSS1 h ≥ 14, ΔNIHSS30 min ≤ 1 and ΔNIHSS1 h ≤ 2. In group D (n = 72), the cutoff NIHSS scores were ≥12 at both 30 min and 1 h, and cutoff ΔNIHSS scores were ≤2 at 30 min and ≤7 at 1 h; 90% of patients with unfavorable outcome showed ΔNIHSS1 h ≤ 7. Conclusion: NIHSS and ΔNIHSS during 1-h rt-PA infusion seemed predictive of 3-month outcome when the site of arterial occlusion was identified prior to rt-PA.
机译：背景和目的：基于在1-H静脉施用重组组织型纤溶酶原激活剂（RT-PA）的1-H静脉施用期间，基于国家健康卒中量表（NIHSS）评分确定了卒中结果的预测指标。方法：从一个预期单中心登记次，回顾性地研究了患有基线NIHSS≥8分和闭塞的脑卒中患者，并在内部颈动脉（ICA，MCA）中闭塞。在RT-PA输注后30分钟和1小时评估基线评分（ΔniHS）的分数和逆变化。患者根据动脉闭塞位点分为两组：P组，ICA或近端M1;和D组，远端M1或M2。 3个月的修改Rankin Scale得分为2-6分为不利的结果。结果：在所有108名患者中，预测不利结果的截止NIHSS评分≥12，并且在30分钟和1小时内切断ΔniHSSss≤2。在P组（n = 36）中，截止NIHSS得分≥14在30分钟内≥14，并且在1小时内截止ΔniHSs得分≤1≤2在1小时。在NIHSS1H≥14的所有患者中可以看到不利的结果，ΔniHS30分钟≤1和Δ1h≤2.在D组（n = 72）中，在30分钟和1小时内，截止NIHSS分数≥12，并截止ΔniHSS分数在30分钟后≤2，≤7位为1小时; 90％的患者的不利结果显示ΔniHS1h≤7.结论：在RT-PA之前鉴定出动脉闭塞的部位时，NIHSS和ΔniHS在1-H RT-PA输注期间似乎预测到了3个月的结果。

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