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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Atherosclerosis in Trial of Org 10172 in Acute Stroke Treatment Subtypes among Young and Middle-Aged Stroke Patients: The Norwegian Stroke in the Young Study
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Atherosclerosis in Trial of Org 10172 in Acute Stroke Treatment Subtypes among Young and Middle-Aged Stroke Patients: The Norwegian Stroke in the Young Study

机译：青年和中年卒中患者急性卒中治疗亚型的Org 10172试验中的动脉粥样硬化：年轻研究中的挪威卒中

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Background: Ischemic stroke patients subtyped as of undetermined cause (SUC) usually outnumber those with determined cause subtypes. Etiological stroke classifications may lead to neglect of parallel, noncausative findings. Atherosclerosis progresses over decades and is associated with high morbidity and mortality in young stroke patients in long-term follow-up studies. We compared the prevalence of carotid atherosclerosis in all TOAST subtypes among young patients with acute ischemic stroke. Methods: We investigated 150 patients aged 15-60 years with documented acute ischemic stroke, and 84 controls free of cardiovascular disease. Stroke etiology was classified according to TOAST criteria. Carotid intima-media thickness (cIMT) measurements were obtained from 12 standardized multiangle measurements in the common carotid artery, carotid bifurcation, and internal carotid artery. Results: The causes of stroke were 5.3% large-artery atherosclerosis (LAA), 26.7% cardioembolism, 21.3% small-artery occlusion (SAO), 10% stroke of other determined cause, and 36.7% stroke of undetermined cause (SUC). cIMT was increased in patients with LAA (1.56 mm, P = .002), SAO (1.11 mm, P = .006), and SUC (1.10 mm, P = .004) compared to controls (cIMT 0.86 mm). Segmental cIMT distribution differed across stroke subtypes, age groups, and sexes. Conclusions: Atherosclerotic disease is prevalent in the majority of young and middle-aged ischemic stroke patients, requiring determined investigation and aggressive treatment of modifiable risk factors.
机译：背景：因原因未明（SUC）而亚型的缺血性卒中患者通常比具有确定的病因亚型的患者要多。病因性卒中分类可能会导致忽略平行的，无原因的发现。长期随访研究显示，动脉粥样硬化进展数十年，并与中风年轻患者的高发病率和高死亡率有关。我们比较了急性缺血性卒中的年轻患者中所有TOAST亚型中颈动脉粥样硬化的患病率。方法：我们调查了150名15-60岁的急性缺血性卒中患者和84名无心血管疾病的对照。中风病因根据TOAST标准分类。颈内膜中层厚度（cIMT）测量是从颈总动脉，颈分叉和颈内动脉的12个标准化多角度测量中获得的。结果：中风的原因为5.3％大动脉粥样硬化（LAA），26.7％心脏栓塞，21.3％小动脉闭塞（SAO），其他确定原因的10％中风和未确定原因（SUC）的36.7％。与对照组（cIMT 0.86 mm）相比，LAA（1.56 mm，P = .002），SAO（1.11 mm，P = .006）和SUC（1.10 mm，P = .004）患者的cIMT升高。分段cIMT分布在卒中亚型，年龄组和性别之间有所不同。结论：动脉粥样硬化疾病在大多数年轻和中年缺血性中风患者中普遍存在，需要确定的研究和积极治疗可改变的危险因素。

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