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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Relationship Between Plasma D-Dimer Concentrations and Acute Ischemic Stroke Subtypes
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The Relationship Between Plasma D-Dimer Concentrations and Acute Ischemic Stroke Subtypes

机译：血浆D-二聚体浓度与急性缺血性卒中亚型的关系

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Elevated concentrations of D-dimers (DDs) in patients with acute ischemic stroke may cause differential diagnostic problems with regard to pulmonar or deep venous thrombosis. The true relationship between plasma DDs and acute ischemic stroke remains uncertain. We studied acute stroke patients admitted to a single acute neurology department with a specialized stroke unit. As part of our clinical protocol, blood samples of each patient had been taken within the first 24 hours after the onset of stroke symptoms and before anticoagulant treatment had been started, to evaluate the coagulation profile. Each patient's medical record was reviewed, and demographic, clinical, laboratory and neuroimaging information was abstracted. Univariate and multivariate statistical analyses were performed. A total of 59 patients admitted to our stroke unit between October 2003 and March 2004 with different stroke subtypes according to the TOAST criteria were evaluated to characterize the impact of stroke category on DD concentration. Family members (n = 23) served as controls in this study. Multivariate regression analysis revealed that patients who sustained cardioembolic stroke had significantly higher DD concentrations than controls and patients who sustained transient ischemic attacks. We identified a correlation between plasma DD levels and different acute ischemic stroke subtypes before any stroke treatment was started. Thus DD concentrations may be considered a direct consequence of marked cerebral infarction and may be useful for physicians when making decisions on treatment for acute ischemic stroke.
机译：急性缺血性卒中患者中D-二聚体（DDs）的浓度升高，可能引起关于肺部或深静脉血栓形成的鉴别诊断问题。血浆DD与急性缺血性卒中之间的真正关系仍然不确定。我们研究了由专门的卒中部门进入单个急性神经内科的急性卒中患者。作为我们临床规程的一部分，在中风症状发作后和开始抗凝治疗之前的最初24小时内采集了每个患者的血液样本，以评估其凝结情况。审查了每个患者的病历，并提取了人口统计学，临床，实验室和神经影像信息。进行了单变量和多变量统计分析。根据TOAST标准，对2003年10月至2004年3月在我们卒中科住院的59例具有不同卒中亚型的患者进行了评估，以表征卒中类别对DD浓度的影响。本研究以家庭成员（n = 23）为对照。多元回归分析显示，患有心脏栓塞性中风的患者的DD浓度明显高于对照组和患有短暂性脑缺血发作的患者。在任何中风治疗开始之前，我们确定了血浆DD水平与不同的急性缺血性中风亚型之间的相关性。因此，DD浓度可能被认为是明显的脑梗死的直接结果，对于医师决定急性缺血性卒中的治疗可能有用。

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