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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Living Well with Stroke: Design and Methods for a Randomized Controlled Trial of a Psychosocial Behavioral Intervention for Poststroke Depression
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Living Well with Stroke: Design and Methods for a Randomized Controlled Trial of a Psychosocial Behavioral Intervention for Poststroke Depression

机译：与中风共存：中风后抑郁的社会心理行为干预的随机对照试验的设计和方法

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Background: Depression is a sufficiently common sequela of a completed stroke to warrant intervention to improve mood, social, and functional outcome. Pharmacologictrials suggest short-term mood improvement from antidepressant treatment but no studies to date have determined whether these short-term gains can be enhanced and extended by a brief psychosocial/behavioral intervention delivered by advanced practice nurses. In addition, drug trials have not reported on functional outcomes such as limitations in ability, limitations in participation, and overall quality of survival. This randomized controlled trial was designed to evaluate the short- and long-term efficacy of a new brief psychosocial/behavioral intervention adjunctive to antidepressant treatment in reducing poststroke depression and improving functional outcomes. Methods: A total of 101 survivors of ischemic stroke with poststroke depression were randomly assigned to receive a brief psychosocial/behavioral intervention plus antidepressant orusual care, including antidepressants. Results: The primary outcome was reduction in depressive symptom severity (Hamilton Depression Rating Scale) at 12 months after stroke. Secondary outcomes were reductions in limitations in activity (Barthel Index), reduction in limitation in participation, and overall stroke impact (Stroke Impact Scale) at 6, 12, and 24 months poststroke. Factors influencing best response to psychosocial intervention were also explored. Conclusion: This article provides detail on the design and treatment methods of this randomized trial in progress. Findings from this study provide important information regarding the long-term efficacy of such a behavioral intervention in reducing poststroke depression and subsequent impaired aspects of psychosocial and physical recovery.
机译：背景：抑郁症是中风完全发作的后遗症，需要干预以改善情绪，社交和功能结局。药理学研究表明，抗抑郁药治疗可以使短期情绪得到改善，但迄今为止，尚无研究确定高级实践护士进行的简短的社会心理/行为干预是否可以增强和扩展这些短期收益。此外，药物试验尚未报告功能性结果，例如能力限制，参与限制和总体生存质量。这项随机对照试验旨在评估一种新的简短的社会心理/行为干预措施（作为抗抑郁药的辅助措施）在减少卒中后抑郁和改善功能结局方面的近期和长期疗效。方法：总共101名缺血性卒中伴卒中后抑郁的幸存者被随机分配接受简短的社会心理/行为干预以及抗抑郁药的日常护理，包括抗抑郁药。结果：主要结果是卒中后12个月抑郁症状严重程度降低（汉密尔顿抑郁量表）。次要结果是中风后6、12和24个月活动限制（Barthel Index）减少，参与限制减少和整体中风影响（Stroke Impact Scale）。还探讨了影响对社会心理干预最佳反应的因素。结论：本文详细介绍了该正在进行的随机试验的设计和治疗方法。这项研究的发现提供了有关这种行为干预措施在减少中风后抑郁以及随后造成的心理和身体康复方面长期有效的重要信息。

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