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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >A Reversible Middle Cerebral Artery Occlusion Model Using Intraluminal Balloon Technique in Monkeys
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A Reversible Middle Cerebral Artery Occlusion Model Using Intraluminal Balloon Technique in Monkeys

机译：利用管腔内气球技术在猴子中建立可逆性中脑动脉闭塞模型

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Background: This study was designed to develop a simple, reversible primate middle cerebral artery (MCA) occlusion (MCAO) model Methods: MCAO was achieved by inserting a specially designed intraluminal balloon catheter from the external carotid artery, then to the internal carotid artery, and finally into the proximal segment of MCA using 13 adolescent monkeys (Macaca mulatto) weighing 4 25 (+-) 0 23 kg The infarction was confirmed by magnetic resonance imaging at 3, 7, and 23 hours after MCAO Results- Local cerebral blood flow in the caudate nucleus decreased remarkably. Post-MCAO electroencephalographic monitoring showed the inhibition of electroencephalography with slow waves distinctly increasing Neurologic evaluation demonstrated persistent deficits in the ischemic group Neuropathologic examinations were consistent with the neuiologic evaluations Conclusion: I he results suggested that this reversible monkey model resembled a human stroke and should offer a reasonable alternative to aaniotomy and the extrinsic ligation of the MCA in the laboratory investigation of focal reversible ceiebral ischemia.
机译：背景：本研究旨在开发一种简单的可逆的灵长类大脑中动脉（MCA）闭塞（MCAO）模型。方法：MCAO是通过从颈外动脉插入特别设计的腔内球囊导管，然后将其插入颈内动脉而实现的，最后，使用13只重4 25（+-）0 23 kg的青春期猴子（Macaca mulatto）进入MCA的近端段。在MCAO结果后3、7和23小时通过磁共振成像证实了梗塞-局部脑血流在尾状核中明显减少。 MCAO后的脑电图监测表明，慢波对脑电图的抑制作用明显增加。神经病学评估表明缺血组存在持续性缺陷。神经病理学检查与神经病学评估一致。结论：我的结果表明，这种可逆的猴子模型类似于人中风，应提供在局灶性可逆性脑缺血的实验室研究中，是开腹手术和MCA外在结扎的合理替代方案。

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