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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Signs and Symptoms of Sleep Apnea and Acute Stroke Severity: Is Sleep Apnea Neuroprotective?
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Signs and Symptoms of Sleep Apnea and Acute Stroke Severity: Is Sleep Apnea Neuroprotective?

机译：睡眠呼吸暂停的症状和体征和急性中风的严重程度：睡眠呼吸暂停对神经有保护作用吗？

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Background: In animal models, brief periods of hypoxemia render the brain tolerant to subsequent ischemic insults. Sleep apnea leads to frequent episodes of nocturnal hypoxemia and may induce ischemic tolerance. Snoring and daytime sleepiness are cardinal symptoms of sleep apnea. We undertook this study to determine differences in stroke severity and early neurologic course in patients at risk for sleep apnea as determined by a sleep questionnaire. Methods: Patients admitted with acute ischemic stroke completed the Berlin questionnaire. The Berlin questionnaire examines habitual snoring, daytime sleepiness, presence of hypertension, and body mass index (BMI) and classifies patients into a high or low risk for sleep apnea group. National Institutes of Health Stroke Scale (NIHSS) score was determined on admission and day 5 of hospitalization. Age, sex, cardiovascular risk factors, BMI, and stroke mechanism were determined prospectively. Results: We enrolled 190 patients with a mean age of 60 years and 53% were men. The Berlin questionnaire classified 103 patients (54%) at high risk for sleep apnea. The median NIHSS score on admission and day 5 of hospitalization did not differ between the two groups after multivariate analysis. Examined separately, we found no effect of snoring, daytime sleepiness, or BMI on acute stroke severity and outcome. Conclusion: We found that a large number of patients admitted with acute ischemic stroke were at high risk for having sleep apnea. We were not able to show that a constellation of symptoms and features highly suggestive of sleep apnea influenced stroke severity or early neurologic course after acute ischemic stroke.
机译：背景：在动物模型中，短暂的低氧血症使大脑对随后的缺血性损伤具有耐受性。睡眠呼吸暂停会导致夜间低氧血症频繁发作，并可能引起缺血耐受。打和白天嗜睡是睡眠呼吸暂停的主要症状。我们进行了这项研究，以确定由睡眠问卷确定的有睡眠呼吸暂停风险的患者的卒中严重程度和早期神经系统病程的差异。方法：急性缺血性卒中的患者填写了柏林问卷。柏林问卷调查了习惯性打nor，白天嗜睡，高血压的存在和体重指数（BMI），并将患者分为睡眠呼吸暂停高风险组或低风险组。美国国立卫生研究院卒中量表（NIHSS）评分是在入院和住院第5天确定的。前瞻性确定年龄，性别，心血管危险因素，BMI和中风机制。结果：我们纳入了190例平均年龄为60岁的患者，其中53％为男性。柏林调查表将103例（54％）高睡眠呼吸暂停风险患者分类。多元分析后，两组患者入院和住院第5天的NIHSS中位数无差异。单独检查，我们发现打ing，白天嗜睡或BMI对急性中风的严重程度和预后没有影响。结论：我们发现，大量急性缺血性卒中患者有睡眠呼吸暂停的高风险。我们未能显示出症状和特征高度提示睡眠呼吸暂停会影响卒中严重程度或急性缺血性卒中后的早期神经系统病程。

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