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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association of Carotid Artery Atherosclerosis With Circulating Biomarkers of Extracellular Matrix Remodeling: The Framingham Offspring Study
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Association of Carotid Artery Atherosclerosis With Circulating Biomarkers of Extracellular Matrix Remodeling: The Framingham Offspring Study

机译：颈动脉粥样硬化与细胞外基质重塑的循环生物标志物的关联：Framingham后代研究

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Objective: We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound. Background: Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) regulate extracellular matrix remodeling, a key feature of atherosclerosis, and their circulating concentrations can be assayed. MMP-9, TIMP-1, and protocol-lagen-III n-terminal propeptide (PIIINP) may relate differentially to the severity of atherosclerosis at different carotid artery sites. However, data examining this premise are sparse. Methods: We related circulating MMP-9, TIMP-1, and/or PIIINP concentrations to carotid atherosclerosis on duplex ultrasound in 1006 Framingham offspring (mean age 58 years, 56% women) who attended a routine examination from 1995 to 1998. We used multivariable regression to relate MMP-9 (detectable v undetectable), TIMP-1, and PIUNP (age- and sex-specific quartiles) to internal carotid artery (IC) stenosis (>25%) and log-transformed common carotid artery and IC intima-media thickness (IMT). Results: Detectable MMP-9 was associated with carotid stenosis (odds ratio [OR] 1.71, P = .032) but not with IMT. Higher TIMP-1 was associated with carotid stenosis (OR for Quartiles (Q)4 v Ql-3, 1.63, P = .022) and a higher IC IMT (fi 0.057 +- 0.025, Q4 v Ql-3, P = .023). Higher PIIINP (Q4 v Ql-3) showed a borderline association with carotid stenosis (OR 1.45 for Q4 v Ql-3, P = .095) but not with IMT. TIMP-1 was not associated with common carotid artery IMT. Conclusions: In our community-based sample of middle-aged to older adults, higher circulating biomarkers of matrix remodeling were associated with a greater prevalence of carotid stenosis and subclinical atherosclerosis in the IC. Our findings are consistent with regional differences in matrix remodeling in the carotid artery.
机译：目的：我们试图将细胞外基质更新的循环生物标志物与双工超声上颈动脉粥样硬化的特定部位测量联系起来。背景：基质金属蛋白酶（MMPs）和组织MMPs抑制剂（TIMPs）调节细胞外基质重塑，这是动脉粥样硬化的关键特征，可以测定其循环浓度。 MMP-9，TIMP-1和协议Lagen-III n末端前肽（PIIINP）可能与不同颈动脉部位动脉粥样硬化的严重程度存在差异。但是，检查此前提的数据很少。方法：我们将1995年至1998年接受例行检查的1006名弗雷明汉后代（平均年龄58岁，女性56％）的双超声检查中循环的MMP-9，TIMP-1和/或PIIINP浓度与颈动脉粥样硬化相关。多变量回归将MMP-9（可检测到不可检测），TIMP-1和PIUNP（年龄和性别特异性四分位数）与颈内动脉（IC）狭窄（> 25％）和对数转换的颈总动脉和IC相关内膜中层厚度（IMT）。结果：可检测的MMP-9与颈动脉狭窄相关（比值比[OR] 1.71，P = .032），而与IMT无关。较高的TIMP-1与颈动脉狭窄（四分位数（Q）4 v Ql-3，1.63，P = .022）和较高的IC IMT（fi 0.057 +-0.025，Q4 v Ql-3，P =。 023）。较高的PIIINP（Q4 v Q1-3）与颈动脉狭窄之间存在临界关联（Q4 v Q1-3的OR为1.45，P = .095），但与IMT无关。 TIMP-1与颈总动脉IMT不相关。结论：在我们以社区为基础的中年至老年人样本中，基质重塑的循环生物标志物较高与IC中颈动脉狭窄和亚临床动脉粥样硬化的患病率更高有关。我们的发现与颈动脉基质重构的区域差异一致。

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