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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study
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Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study

机译：弗雷明汉后代研究中血浆同型半胱氨酸水平与颈动脉内膜中膜厚度之间的节段特异性关联

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Elevated plasma total homocysteine (tHcy) level is an established risk factor for cardiovascular disease. The relationship between tHcy and carotid artery intima-media thickness (IMT) at the internal carotid artery (ICA)/bulb-IMT and common carotid artery (CCA)-IMT had not been systematically studied, however. Because the ICA/bulb segment is more prone to plaque formation than the CCA segment, differential associations with tHcy at these sites might suggest mechanisms of tHcy action. We examined the cross-sectional segment-specific relationships of tHcy to ICA/bulb-IMT and CCA-IMT in 2499 participants from the Framingham Offspring Study who were free of cardiovascular disease. In multivariate linear regression analysis, ICA/bulb-IMT was significantly higher in the fourth tHcy quartile category compared with the other quartile categories, in both the age- and sex-adjusted and the multivariate-adjusted models (P for trend <.0001 and <.01, respectively). We observed a significant age-by-tHcy interaction for ICA/bulb-IMT (P = .03) and thus stratified the analyses by median age (58 years). A significant positive trend between tHcy and ICA/bulb-IMT was seen in individuals age ≥58 years (P for trend <.01), but not in younger individuals (P for trend = .24) in multivariate-adjusted models. For CCA-IMT, no significant trends were observed in any of the analyses. The segment-specific association between elevated tHcy level and ICA/bulb-IMT suggests an association between tHcy and plaque formation.
机译：血浆总同型半胱氨酸（tHcy）水平升高是心血管疾病的既定危险因素。然而，尚未系统研究tHcy与颈内动脉（ICA）/球-IMT和颈总动脉（CCA）-IMT的颈动脉内中膜厚度（IMT）之间的关系。由于ICA /鳞茎节段比CCA节段更易于形成斑块，因此在这些位点与tHcy的不同关联可能暗示了tHcy作用的机制。我们在弗雷明汉后代研究的2499名无心血管疾病的参与者中检查了tHcy与ICA / bulb-IMT和CCA-IMT的横断面特异性关系。在多元线性回归分析中，在年龄和性别校正及多元校正模型中，第四个tHcy四分位数类别的ICA / bulb-IMT显着高于其他四分位数类别（趋势<.0001和分别<.01）。我们观察到ICA / bulb-IMT的逐年龄tHcy交互作用显着（P = .03），因此按中位年龄（58岁）进行了分层分析。在多变量校正模型中，年龄≥58岁的个体（趋势<.01的P）中发现tHcy与ICA / bulb-IMT之间有显着的正趋势，而年轻的个体（趋势P = .24）则没有。对于CCA-IMT，在任何分析中均未观察到明显的趋势。 tHcy水平升高与ICA / bulb-IMT之间的片段特异性关联提示tHcy与斑块形成之间的关联。

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