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首页> 外文期刊>Journal of surface investigation: x-ray, synchrotron and neutron techniques >Comparative Analysis of Sensory Rhodopsin II Structures in Complex with a Transducer and without It
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Comparative Analysis of Sensory Rhodopsin II Structures in Complex with a Transducer and without It

机译：具有传感器和不具有传感器的复合物中感觉视紫红质II结构的比较分析

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摘要

Sensory rhodopsin 11(NpSRI1) is a heptahelical transmembrane protein containing the retinal chromophore. In complex with another membrane protein, i.e., NpHtrII transducer, NpSRII transmits a signal into a cell, initiating negative phototaxis of Natronobacterium pharaonis. In the absence of a transducer, rhodopsin II can work as a proton pump similar to bacteriorhodopsin. The main objective of this study is to comparatively analyze receptor structures in complex with the transducer and without it to understand the mechanism of the protein switching function. Diffraction data for sensory rhodopsin II crystals grown in the lipidic cubic phase were obtained at the synchrotron x-ray source. In this paper, we present a new NpSRII structure with a resolution of 2.1 A and the results of a comparative analysis of the obtained NpSRII structure with our previously published data on the NpSRII/NpHtrII complex structure and with two NpSRII structures without a transducer, previously published in the literature.
机译：感觉视紫红质11（NpSRI1）是一种包含视网膜发色团的七螺旋跨膜蛋白。与另一种膜蛋白（即NpHtrII传感器）复合时，NpSRII将信号传输到细胞中，从而引发法老氏杆菌的负趋光性​​。在没有换能器的情况下，视紫红质II可以用作质子泵，类似于细菌视紫红质。这项研究的主要目的是比较分析与换能器复杂的受体结构，而无需了解换能器的机理。在同步加速器X射线源获得在脂质立方相中生长的感觉视紫红质II晶体的衍射数据。在本文中，我们提出了一种分辨率为2.1 A的新NpSRII结构，并使用我们先前发布的有关NpSRII / NpHtrII复杂结构以及具有两个没有换能器的NpSRII结构的数据，对获得的NpSRII结构进行了比较分析的结果在文献中发表。

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