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首页> 外文期刊>Journal of substance abuse treatment >Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: A National Drug Abuse Treatment Clinical Trials Network study
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Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: A National Drug Abuse Treatment Clinical Trials Network study

机译：使用潜在变量方法了解可卡因依赖性的性别和种族/种族差异：国家药物滥用治疗临床试验网络研究

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This study applies a latent variable approach to examine gender and racial/ethnic differences in cocaine dependence, to determine the presence of differential item functioning (DIF) or item-response bias to diagnostic questions of cocaine dependence, and to explore the effects of DIF on the predictor analysis of cocaine dependence. The analysis sample included 682 cocaine users enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN). Participants were recruited from 14 community-based substance abuse treatment programs associated with the CTN, including 6 methadone and 8 outpatient nonmethadone programs. Factor and multiple indicators-multiple causes (MIMIC) procedures evaluated the latent continuum of cocaine dependence and its correlates. MIMIC analysis showed that men exhibited lower odds of cocaine dependence than women (regression coefficient, (5= -0.34), controlling for the effects of DIF, years of cocaine use, addiction treatment history, comorbid drug dependence diagnoses, and treatment setting. There were no racial/ethnic differences in cocaine dependence; however, DIF by race/ethnicity was noted. Within the context of multiple community-based addiction treatment settings, women were more likely than men to exhibit cocaine dependence. Addiction treatment research needs to further evaluate gender-related differences in drug dependence in treatment entry and to investigate how these differences may affect study participation, retention, and treatment response to better serve this population. ? 2010 Elsevier Inc. All rights reserved.
机译：这项研究采用潜在变量方法来检查可卡因依赖的性别和种族/种族差异，以确定可卡因依赖诊断问题的差异项功能（DIF）或项响应偏倚的存在，并探讨DIF对可卡因的诊断问题可卡因依赖的预测因素分析。分析样本包括682名可卡因使用者，他们参加了国家药物滥用治疗临床试验网络（CTN）的两项国家多站点研究。参加者来自与CTN相关的14个基于社区的药物滥用治疗计划，包括6个美沙酮和8个门诊非美沙酮计划。因素和多指标多原因（MIMIC）程序评估了可卡因依赖及其相关因素的潜在连续性。 MIMIC分析显示，男性对可卡因的依赖比女性低（回归系数，（5 = -0.34），控制DIF的影响，可卡因的使用年限，成瘾的治疗史，合并毒品依赖诊断和治疗环境。可卡因依赖性没有种族/种族差异;但是，注意到了种族/民族的DIF;在多种基于社区的成瘾治疗背景下，女性比男性更容易表现出可卡因依赖性。成瘾治疗研究需要进一步评估治疗进入药物依赖性方面的性别相关差异，并调查这些差异如何影响研究的参与，保留和治疗反应，从而更好地为该人群提供服务？2010 Elsevier Inc.保留所有权利。

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