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首页> 外文期刊>Journal of the American Pharmacists Association: JAPhA >New drugs: Febuxostat, lacosamide, and rufinamide.
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New drugs: Febuxostat, lacosamide, and rufinamide.

机译：新药：非布索坦，拉考酰胺和芦丁酰胺。

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摘要

Approximately 5 million Americans suffer from gout, which Is the most common Inflammatory arthritis In men older than 40 years. Gout Is a chronic condition characterized by attacks, or "flares," that are marked by Intense pain, redness, swelling, and heat In the affected joint, These symptoms result from an acute Inflammatory response to the presence of crystallized uric acid In the jolnt(s). Uric acld Is an end product formed when the body breaks down purines. Hypemrl-cemla occurs when this process results in elevated uric acld concentrations as a consequence of overproduction and/or un-derexcretlon of uric acid. Hyperuricemla is a precursor to gout, and the higher an individual's uric acid concentration, the greater the risk for developing gout, A goal In treating chronic gout is reducing and maintaining serum uric acid concentrations less than 6 mg/dL.
机译：大约有500万美国人患有痛风，痛风是40岁以上男性中最常见的炎症性关节炎。痛风是一种慢性疾病，特征在于发作，或“耀斑”，其特征在于受影响关节的剧烈疼痛，发红，肿胀和发热。这些症状是由于对结晶尿酸的急性炎症反应而产生的。 （s）。尿酸acld是人体分解嘌呤时形成的最终产物。当此过程导致尿酸过分生产和/或过表达不足时，尿酸acld浓度升高，就会发生Hypemrl-cemla。 Hyperuricemla是痛风的前兆，个体的尿酸浓度越高，患痛风的风险就越大。治疗慢性痛风的目标是降低并维持血清尿酸浓度低于6 mg / dL。

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