• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Cortical inhibition in motor and non-motor regions: a combined TMS-EEG study.
【24h】

Cortical inhibition in motor and non-motor regions: a combined TMS-EEG study.

机译：运动和非运动区域的皮质抑制：TMS-EEG组合研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A number of studies using paired pulse transcranial magnetic stimulation (TMS) have demonstrated that cortical inhibition (CI) of the motor cortex can be recorded and also gauged through surface electromyography. However, recording CI from other brain regions that are more directly related with the pathophysiology of some neurologic and psychiatric disorders (e.g., dorsolateral prefrontal cortex (DLPFC) in schizophrenia) was previously fraught with technical difficulties. This study was therefore designed to examine, through a combination of TMS with EEG, whether CI could be measured directly from the motor cortex, DLPFC, and another non-motor region. To index CI, long interval cortical inhibition (LICI; a TMS paradigm) was used in the motor cortex and DLPFC in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. In the motor cortex, LICI resulted in a significant suppression in mean cortical evoked activity on EEG (37.31 +/- 47.51%). In the DLPFC, LICI resulted in a significant suppression (32.45 +/- 47.86%) in mean cortical evoked activity and did not correlate with LICI in the motor cortex although they did not significantly differ. In the parietal lobe, LICI resulted in significant suppression (47.76 +/- 44.70%) in mean cortical evoked activity. In conclusion, CI in the dorsolateral prefrontal cortex, motor cortex and parietal cortex were similar at 120% of motor threshold. These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurologic and psychiatric disorders.
机译：使用成对脉冲经颅磁刺激（TMS）进行的许多研究表明，可以记录运动皮层的皮质抑制（CI）并通过表面肌电图进行测量。但是，从其他大脑区域记录与某些神经系统和精神疾病（例如，精神分裂症的背外侧前额叶皮层（DLPFC））的病理生理学更直接相关的CI以前充满了技术难题。因此，本研究旨在通过结合TMS和EEG来检查是否可以直接从运动皮层，DLPFC和另一个非运动区域测量CI。为了对CI进行索引，在14位健康受试者的运动皮质和DLPFC中以及在其中5位受试者的顶叶中使用了长时程皮质抑制（LICI; TMS范例）。在运动皮层中，LICI导致对EEG的平均皮层诱发活动的显着抑制（37.31 +/- 47.51％）。在DLPFC中，LICI导致平均皮层诱发活动受到显着抑制（32.45 +/- 47.86％），并且与运动皮层中的LICI不相关，尽管它们没有显着差异。在顶叶中，LICI导致平均皮层诱发活动受到显着抑制（47.76 +/- 44.70％）。总之，背侧前额叶皮层，运动皮层和顶叶皮层的CI在运动阈值的120％时相似。这些数据表明，可以通过将TMS与EEG结合来记录CI，并且可能有助于未来的研究，试图确定CI在几种神经系统和精神疾病的病理生理中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号