• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >An animal model to study the clinical significance of interictal spiking.
【24h】

An animal model to study the clinical significance of interictal spiking.

机译：用于研究发作间期的临床意义的动物模型。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Interictal spikes (IIS) are paroxysmal discharges commonly observed in patients with epilepsy which represent an abnormally-synchronized population of hyperexcitable neurons firing as an aggregate. Due to conflicting studies on the clinical significance of IIS, research focusing on IIS has been sparse. However, recent attention on IIS has increased for patients undergoing surgery for intractable epilepsy as a means to identify epileptic foci for surgical resection. There is growing evidence that IIS are not asymptomatic as has been commonly accepted. Other than epilepsy, IIS have been associated with a wide range of behavioral and psychiatric disorders, including attention deficit disorder, anxiety disorders and psychoses. For these reasons, a well-characterized animal model of interictal spiking which accurately mimics the human phenomenon would be a valuable tool to gain, insights both into the pathophysiology of epilepsy as well as a broad variety of human neuropsychiatric diseases. Here, we review the literature on the clinical significance of IIS in humans and on animal models where IIS has been observed. We then demonstrate the utility of using tetanus toxin to generate a reproducible pattem of progressive IIS for future studies into their clinical significance.
机译：发作间期放电（IIS）是癫痫患者中常见的阵发性放电，代表异常兴奋的高兴奋性神经元聚集放电。由于对IIS的临床意义的研究存在矛盾，因此针对IIS的研究很少。但是，最近对于难治性癫痫手术患者的IIS越来越多地关注，这是鉴定癫痫灶进行手术切除的一种手段。越来越多的证据表明IIS并非像通常所接受的那样没有症状。除癫痫外，IIS还与多种行为和精神疾病有关，包括注意缺陷症，焦虑症和精神病。由于这些原因，一个能很好地模仿人类现象的特征丰富的动物间壁刺模型将是获得有价值的工具，可以深入了解癫痫的病理生理学以及各种人类神经精神疾病。在这里，我们回顾了有关IIS在人类中的临床意义以及已经观察到IIS的动物模型的文献。然后，我们证明了使用破伤风毒素来产生进行性IIS的可再现模式的实用性，以供将来对其临床意义进行研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号