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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Antiepileptic drugs and mood stability.
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Antiepileptic drugs and mood stability.

机译：抗癫痫药和情绪稳定。

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This paper will discuss different definitions of the term "mood stabilizer" and highlight in detail the antiepileptic drugs carbamazepine, valproate and lamotrigine with respect to their relative strengths in stabilizing mood in bipolar patients. These drugs are heterogeneous in their mechanisms of action and in their efficacy to stabilize patients with epilepsy and the various mood states in bipolar disorder. Lamotrigine has obtained approval in several countries for the indication of preventing bipolar depressive episodes, which raises the question of differential efficacy of other antiepileptic drugs as mood stabilizers in the prevention of either depressive or hypo-/manic episodes. A Medline Search to 2006 was conducted for controlled acute and maintenance studies of the three scientifically and clinically most established antiepileptic drugs carbamazepine, valproate and lamotrigine. The medications discussed in this review only partly fulfill definitions of a mood stabilizer, and we suggest that future research should focus on combined treatment strategies.
机译：本文将讨论“情绪稳定剂”一词的不同定义，并详细介绍抗癫痫药卡马西平，丙戊酸盐和拉莫三嗪在稳定双相型患者情绪方面的相对优势。这些药物在作用机制和稳定癫痫患者以及双相情感障碍中各种情绪状态的功效方面是异质的。拉莫三嗪在预防双相抑郁发作中的适应症已在多个国家获得批准，这引发了其他抗癫痫药作为情绪稳定剂在预防抑郁症或低躁狂发作中的不同功效的问题。进行了2006年Medline搜索，以对三种科学和临床上最成熟的抗癫痫药卡马西平，丙戊酸盐和拉莫三嗪进行急性和维持性对照研究。在这篇综述中讨论的药物仅部分满足了情绪稳定剂的定义，我们建议未来的研究应侧重于联合治疗策略。

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