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首页> 外文期刊>Clinical nephrology >Treatment with cyclosporine A improves SLE disease activity of Japanese patients with diffuse proliferative lupus nephritis.
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Treatment with cyclosporine A improves SLE disease activity of Japanese patients with diffuse proliferative lupus nephritis.

机译：环孢素A的治疗可改善日本弥漫性增生性狼疮肾炎患者的SLE疾病活动性。

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摘要

AIMS: Cyclosporine A (CyA), a representative calcineurin inhibitor, may be useful for the treatment of lupus nephritis. In contrast to knowledge about its strong effects against proteinuria, however, there is little information about the beneficial effects of CyA against clinical disease activity of diffuse proliferative lupus nephritis. METHODS: To elucidate this issue, we investigated the effects of low-dose CyA treatment (< 2.5 mg/kg/d) in 11 Japanese adult patients (1 male, 10 female) with uncontrolled diffuse proliferative lupus nephritis with severe clinical SLE disease activity. RESULTS: In addition to amelioration of the proteinuric state, the clinical SLE disease activities, estimated by serological markers and the SLE disease activity index (SLEDAI), were significantly improved in all patients within 1 month. The required amounts of corticosteroid were decreased in these patients. These favorable effects continued for 2 y without serious adverse effects. Kidney function was not changed in the patients with satisfactory kidney function prior to CyA therapy (serum creatinine < 1.1 mg/dl, and eGFR > 45 ml/ min/1.73 m2). CONCLUSION: The current study results suggest that low-dose CyA treatment could ameliorate the severe clinical SLE disease activity as well as improve proteinuria in Japanese patients with diffuse proliferative lupus nephritis. This treatment would be safe and useful for SLE patients with satisfactory kidney function.
机译：目的：环孢菌素A（CyA），一种典型的钙调神经磷酸酶抑制剂，可用于治疗狼疮性肾炎。然而，与关于其对蛋白尿的强作用的认识相反，关于CyA对弥漫性增生性狼疮肾炎的临床疾病活性的有益作用的信息很少。方法：为了阐明这个问题，我们调查了低剂量CyA治疗（<2.5 mg / kg / d）对11例日本成人（1例男性，10例女性）成人弥漫性增生性狼疮性肾炎的严重SLE疾病活动的控制。结果：除了改善蛋白尿状态外，通过血清学标志物和SLE疾病活动指数（SLEDAI）评估的临床SLE疾病活动在1个月内所有患者均得到显着改善。这些患者的皮质类固醇需要量减少了。这些有利影响持续了2年，没有严重的不利影响。 CyA治疗前肾功能令人满意的患者的肾功能未改变（血清肌酐<1.1 mg / dl，eGFR> 45 ml / min / 1.73 m2）。结论：目前的研究结果表明，低剂量CyA治疗可改善日本弥漫性增生性狼疮性肾炎患者的严重SLE疾病活动并改善蛋白尿。对于肾功能令人满意的SLE患者，这种治疗是安全有效的。

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