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The effects of mycophenolate mofetil on encapsulated peritoneal sclerosis model in rats

机译：霉酚酸酯对大鼠包膜性腹膜硬化模型的影响

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Introduction: Encapsulated peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis. We aimed to investigate the effects of mycophenolate mofetil (MMF) treatment in experimental EPS in rats. Methods: 40 nonuremic Wistar albino rats were divided equally into 4 groups: control rats received 2 ml isotonic saline intraperitoneally daily for 3 weeks without any other treatment. The chlorhexidine gluconate group received intraperitoneally 2 ml/200 g injection of chlorhexidine gluconate and ethanol dissolved in saline for 3 weeks. The resting group received chlorhexidine gluconate (0 - 3 rd week) + peritoneal resting (4 th - 6 th week). The MMF group received chlorhexidine gluconate (0 - 3 rd week) + 125 mg/l MMF in drinking water (4 th - 6 th week). Dialysate cytokine levels, leukocyte count, peritoneal thickness, inflammation and fibroblast activities were evaluated. Results: Although the MMF and resting groups showed beneficial effects on ultrafiltration and D 1/D 0 glucose compared to the chlorhexidine gluconate group, only MMF treatment improved dialysate TGF-β1, VEGF and MCP-1 levels compared to the resting group. Inflammatory activity and vascularity observed in a tissue biopsy, including capillaries number per mm 2 of submesothelial area, decreased in the treatment group. Conclusions: MMF treatment has beneficial effects on EPS via inhibiting inflammation and neovascularisation by reducing dialysate VEGF overexpression.
机译：简介：封装型腹膜硬化症（EPS）是腹膜透析的毁灭性并发症。我们旨在研究霉酚酸酯（MMF）治疗在大鼠实验性EPS中的作用。方法：将40只非尿毒症Wistar白化病大鼠平均分为4组：对照组大鼠每天腹膜内接受2 ml等渗盐水，持续3周，无需任何其他治疗。葡萄糖酸氯己定组腹腔内注射2 ml / 200 g葡萄糖酸氯己定和乙醇溶解在盐水中3周。静息组接受葡萄糖酸氯己定（0-3周）+腹膜静息（4-6周）。 MMF组接受葡萄糖酸洗必泰（0-3周）+饮用水中125 mg / l MMF（4-6周）。评估透析液的细胞因子水平，白细胞计数，腹膜厚度，炎症和成纤维细胞活性。结果：尽管MMF和静息组与葡萄糖酸洗必太组相比对超滤和D 1 / D 0葡萄糖显示出有益的作用，但与静息组相比，只有MMF治疗可以改善透析液中TGF-β1，VEGF和MCP-1的水平。治疗组在组织活检中观察到的炎性活动和血管减少，包括每mm 2的间皮下区域的毛细血管数目减少。结论：MMF治疗可通过减少透析液VEGF的过表达来抑制炎症和新生血管形成，从而对EPS产生有益作用。

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