Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays [Review]

Boggiano C.; Reixach N.; Pinilla C.; Blondelle SE.

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Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays [Review]

机译：通过在基于复杂细胞的生物测定中筛选基于混合物的肽组合文库，成功鉴定了控制传染病的新型药物[综述]

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Mixture-based peptide synthetic combinatorial libraries (SCLs) represent a valuable source for the development of novel agents to control infectious diseases. Indeed, a number of studies have now proven the ability of identifying active peptides from libraries composed of thousands to millions of peptides in cell-based biosystems of varying complexity. Furthermore, progressing knowledge on the importance of endogenous peptides in various immune responses lead to a regain in importance for peptides as potential therapeutic agents. This article is aimed at providing recent studies in our laboratory for the development of antimicrobial or antiviral peptides derived from mixture-based SCLs using cell-based assays, as well as a short review of the importance of such peptides in the control of infectious diseases. Furthermore, the use of positional scanning (PS) SCL-based biometrical analyses for the identification of native optimal epitopes specific to HIV-1 proteins is also presented. (C) 2003 Wiley Periodicals, Inc. [References: 68]

机译：基于混合物的肽合成组合库（SCL）代表了开发控制感染性疾病的新型药物的宝贵资源。确实，现在有许多研究证明了在复杂程度不同的基于细胞的生物系统中，可以从由数千种肽组成的库中鉴定出活性肽的能力。此外，关于内源肽在各种免疫应答中的重要性的不断发展的知识导致重新获得了作为潜在治疗剂的肽的重要性。本文旨在为我们的实验室提供最新研究，以开发基于细胞的测定法从基于混合物的SCL衍生的抗微生物或抗病毒肽，并对此类肽在控制传染病中的重要性进行简短回顾。此外，还介绍了使用基于位置扫描（PS）SCL的生物特征分析来识别特定于HIV-1蛋白的天然最佳表位。（C）2003 Wiley Periodicals，Inc. [参考：68]

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《Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies》 |2003年第2期|共14页
作者
Boggiano C.; Reixach N.; Pinilla C.; Blondelle SE.;
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正文语种 eng
中图分类分子生物学;
关键词
Antimicrobial peptides; Cytotoxic t-lymphocyte vaccines; Human immunodeficiency virus 1 antagonists; Peptide synthetic combinatorial libraries; Helical antimicrobial peptides; T-lymphocyte responses; Amino-acids; Amphipathic peptides; Synthetic peptides; Hiv-1 replication; Fusion mechanism; Cancer vaccines; Membrane-fusion; Dendritic-cell;

机译：抗菌肽;细胞毒性t淋巴细胞疫苗;人免疫缺陷病毒1拮抗剂;肽合成组合文库;螺旋型抗菌肽;T淋巴细胞反应;氨基酸;两亲性肽;合成肽;Hiv-1复制;融合机制;癌症疫苗;膜融合;树突状细胞;

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1. Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays [Review] [J] . Boggiano C., Reixach N., Pinilla C., Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies . 2003,第2期

机译：通过在基于复杂细胞的生物测定中筛选基于混合物的肽组合文库，成功鉴定了控制传染病的新型药物[综述]
2. Identification of Novel Peptide Ligands for the Cancer-Specific Receptor Mutation EFGRvIII Using a Mixture-Based Synthetic Combinatorial Library [J] . Denholt CL, Hansen PR, Pedersen N, Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies . 2009,第3期

机译：使用基于混合物的合成组合文库，针对癌症特异性受体突变EFGRvIII的新型肽配体的鉴定
3. Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening. [J] . Chien J, He X, Shridhar V Journal of cellular biochemistry. . 2009,第2期

机译：通过基于混合物的定向肽库筛选，鉴定微管蛋白作为丝氨酸蛋白酶HtrA1的底物。
4. Identification of Inhibitors of Protein-Protein Interactions Through the Screening of Simplified Combinatorial Peptide Libraries [C] . Pasqualina L. Scognamiglio, Nunzianna Doti, Carlo Pedone American Peptide Symposium . 2009

机译：通过筛选简化组合肽文库鉴定蛋白质 - 蛋白质相互作用的抑制剂
5. Screening combinatorial peptide libraries in complex mixtures for applications in therapeutic delivery and molecular diagnostics. [D] . Hall, Sejal Sampat. 2008

机译：筛选复杂混合物中的组合肽库，以用于治疗性递送和分子诊断。
6. Identification of Two Novel Potent Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library [O] . Kate J. Reilley, Marc Giulianotti, Colette T. Dooley, 2010

机译：从大型的基于混合物的组合文库的直接体内筛选中鉴定两种新颖的有效的低责任的抗伤害感受性化合物
7. Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library [O] . Reilley, Kate J., Giulianotti, Marc, Dooley, Colette T., 2010

机译：从大型的基于混合物的组合文库的直接体内筛选中鉴定出两种新颖的，有效的，低责任的抗伤害感受性化合物
8. Cell-Based Approach for the Biosynthesis/Screening of Cyclic Peptide Libraries against Bacterial Toxins [R] . Camarero, J. A., Kimura, R., Woo, Y., 2007

机译：基于细胞的方法用于生物合成/筛选针对细菌毒素的环肽库

Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays [Review]

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