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首页> 外文期刊>Journal of the American Academy of Nurse Practitioners. >New findings: Depression, suicide, and Toxoplasma gondii infection
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New findings: Depression, suicide, and Toxoplasma gondii infection

机译：新发现：抑郁，自杀和弓形虫感染

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Purpose: This article provides an overview of the evidence of a potential pathophysiological relationship between depression, suicide, and the Toxoplasma gondii (T. gondii) infection. It discusses the role of inflammatory processes in depressive illness and the infection theory of psychiatric disease. It also provides guidelines for the screening, diagnosis, and treatment of depression for nurse practitioners (NPs).Data source: A narrative review was conducted of the literature from PubMed, PsycINFO, and Google Scholar. References of identified articles were also reviewed.Conclusions: Seropositivity of the obligate intracellular protozoan parasite, T. gondii is related to various mental health disorders including schizophrenia, suicide attempt, depression, and other neuropsychiatric diseases. Depressive symptoms have been linked to interferon-gamma (IFN-gamma) blocking T. gondii growth by inducing indoleamine-2,3-dioxygenase (IDO) activation and tryp-tophan depletion, which results in a decrease of serotonin production in the brain. Although exposure to T. gondii was considered unlikely to reactivate in immune-competent individuals, new findings report that this reactivation may be triggered by immune imbalance.
机译：目的：本文概述了抑郁症，自杀和弓形虫（T. gondii）感染之间潜在的病理生理关系的证据。它讨论了炎症过程在抑郁症中的作用以及精神病的感染理论。它还为护士（NP）的抑郁症的筛查，诊断和治疗提供了指南。数据来源：对PubMed，PsycINFO和Google Scholar的文献进行了叙述性回顾。结论：专性胞内原生动物寄生虫弓形虫的血清阳性与多种精神疾病有关，包括精神分裂症，自杀未遂，抑郁症和其他神经精神疾病。抑郁症状已通过诱导吲哚胺-2,3-双加氧酶（IDO）激活和胰蛋白酶-phan耗尽而与干扰素γ（IFN-γ）阻断弓形虫的生长有关，这导致大脑中5-羟色胺生成的减少。尽管人们认为暴露于弓形虫的人不太可能在具有免疫能力的个体中重新激活，但新发现表明这种重新激活可能是由免疫失衡引起的。

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