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首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >Low-cumulative dose isotretinoin treatment in mild-to-moderate acne: efficacy in achieving stable remission.
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Low-cumulative dose isotretinoin treatment in mild-to-moderate acne: efficacy in achieving stable remission.

机译：低累积剂量异维A酸治疗轻度至中度痤疮：实现稳定缓解的功效。

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BACKGROUND: Aimed at the reduction of post-treatment relapse of severe acne, the cumulative dose of oral isotretinoin should be >/=120 mg/kg. However, data on the appropriate oral isotretinoin treatment regimen in mild and moderate acne are lacking. OBJECTIVE: The purpose of this study was to determine the efficacy of an isotretinoin-sparing protocol in inducing permanent remission of mild and moderate acne. METHODS: In this open, prospective, non-comparative study, 150 patients affected with mild-to-moderate acne were treated with isotretinoin until complete recovery and for a further month of treatment, independent of the total cumulative dose reached. Patients then underwent a 1-year maintenance therapy with adapalene 0.1% cream. Patients were followed up for a further year, without any treatment. RESULTS: A total of 139 patients completed the study. Overall, patients received a mean of 80.92 mg/kg cumulative dose of isotretinoin. In the 2-year follow-up, relapse only appeared in 13 patients (9.35%). CONCLUSION: Comparing our findings with published data, this isotretinoin-sparing regimen was shown to be effective in inducing stable remission and preventing acne relapses in patients with mild-to-moderate acne. Low-cumulative dose regimens may potentially lead to a lower incidence of side-effects and to lower costs than higher doses.
机译：背景：为减少严重痤疮的治疗后复发，口服异维A酸的累积剂量应> / = 120 mg / kg。但是，缺乏关于轻度和中度痤疮的适当口服异维A酸治疗方案的数据。目的：本研究的目的是确定使用异维A酸的方案可诱导轻度和中度痤疮的永久缓解。方法：在这项开放性，前瞻性，非对照研究中，对150名轻度至中度痤疮患者进行了异维A酸治疗，直至完全康复并继续治疗一个月，与总累积剂量无关。然后，患者接受0.1％阿达帕林乳膏1年维持治疗。对患者进行了一年的随访，未进行任何治疗。结果：共有139名患者完成了研究。总体而言，患者接受的平均异维A酸平均剂量为80.92 mg / kg。在2年的随访中，仅13例（9.35％）出现复发。结论：将我们的发现与已发表的数据进行比较，该异维A酸保留方案被证明可有效诱导轻度至中度痤疮患者的稳定缓解并预防痤疮复发。与高剂量相比，低累积剂量方案可能会导致副作用发生率降低和成本降低。

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