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首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases.
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Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases.

机译:生殖支原体:尿道炎和其他性传播疾病的病因。

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摘要

Mycoplasma genitalium was first isolated in 1980 from two of 13 men with non-gonococcal urethritis (NGU). It shares several features with M. pneumoniae, a recognized respiratory tract pathogen. It is extremely difficult to isolate by culture. The development of sensitive and specific polymerase chain reaction (PCR) assays in the early 1990s made clinical studies possible and a significant number of publications have shown a strong association between M. genitalium and NGU, independent of Chlamydia trachomatis. The purpose of this review is to evaluate the currently available information on the associations between M. genitalium and urogenital tract infections in men and women and assess their fulfilment of the Henle-Koch postulates. It is concluded that there is very strong evidence that M. genitalium is a cause of NGU in men and cervicitis in women. Evidence for upper genital tract infections in women has begun to accrue, but further studies are needed. The optimal treatment of M. genitalium infections remains to be determined, but antibiotics of the macrolide group appear to be more active than tetracyclines.
机译:生殖支原体最初于1980年从13名非淋菌性尿道炎(NGU)男性中分离出来。它与公认的呼吸道病原体肺炎支原体具有几个特征。通过文化隔离是极其困难的。在1990年代初期,灵敏和特异性聚合酶链反应(PCR)分析方法的发展使临床研究成为可能,并且大量出版物显示生殖器支原体和NGU之间有很强的联系,而与沙眼衣原体无关。这项审查的目的是评估有关男性和女性生殖器支原体和泌尿生殖道感染之间的关联的当前可用信息,并评估它们是否符合Henle-Koch规定。结论是,有非常有力的证据表明生殖器支原体是男性NGU的成因,女性宫颈炎的成因。女性上生殖道感染的证据已经开始积累,但是还需要进一步的研究。生殖器支原体感染的最佳治疗方法尚待确定,但大环内酯类抗生素似乎比四环素类更具活性。

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