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首页> 外文期刊>Journal of the Korean Society for Applied Biological Chemistry >Characteristics of Cholesterol-lowering Lactobacillus casei subsp. casei strain GL-03 Isolated from Cheese
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Characteristics of Cholesterol-lowering Lactobacillus casei subsp. casei strain GL-03 Isolated from Cheese

机译：降低胆固醇的干酪乳杆菌亚种的特征。从干酪中分离出干酪素菌株GL-03

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Cholesterol-lowering effect of lactic acid bacteria is well-known. In the present study, nine cholesterol-lowering Lactobacillus strains from Chinese traditional cheese, pickle, and yoghurt were screened and characterized for their potential use. The microbial contents of all strains significantly decreased at pH 1.5; however, the residual counts of Lactobacillus casei subsp. casei GL-03, L. plantarum ZP-Z, L. plantarum ZP-05, and L. brevis ZP-04 were more than 10(7) CFU/mL after incubation for 6 h. All nine strains of Lactobacillus indicated good tolerance to bile at concentration less than 0.2% after incubation for 2 to 6 h. L. plantarum ZP-W had maximum hydrophobicity towards xylene, whereas GL-03 strain possessed maximum hydrophobicity for both hexadecane and octane. ZP-05 strain had more effective inhibitory activity against both Staphylococcus aureus and Bacillus subtilis than other eight strains. Furthermore, GL-03 strain significantly reduced cholesterol TC and TG levels in hyperlipidemia mice fed high-cholesterol diet. The growth of GL-03 strain was promoted by five kinds of Chinese herbal medicines, and the Chinese hawthorn at concentration of 0.0125% showed the highest promoting effect. These results suggest that L. casei subsp. casei GL-03 may be effective as a probiotic with cholesterol-lowing activities
机译：乳酸菌的降低胆固醇的作用是众所周知的。在本研究中，从中国传统奶酪，咸菜和酸奶中筛选了九种降低胆固醇的乳酸杆菌菌株，并对其潜在用途进行了表征。在pH 1.5时，所有菌株的微生物含量均显着下降。但是，干酪乳杆菌亚种的残留计数。孵育6小时后，casei GL-03，植物乳杆菌ZP-Z，植物乳杆菌ZP-05和短乳杆菌ZP-04均大于10（7）CFU / mL。孵育2至6小时后，浓度低于0.2％的所有9株乳酸菌均表现出对胆汁的良好耐受性。植物乳杆菌ZP-W具有对二甲苯的最大疏水性，而GL-03菌株对十六烷和辛烷均具有最大疏水性。 ZP-05菌株对金黄色葡萄球菌和枯草芽孢杆菌的抑制活性均比其他8株菌株高。此外，GL-03品系可以显着降低高胆固醇饮食喂养的高脂血症小鼠的胆固醇TC和TG水平。 GL-03菌株的生长受到五种中草药的促进，浓度为0.0125％的山楂具有最高的促进作用。这些结果表明干酪乳杆菌亚种。酪蛋白GL-03可作为具有降低胆固醇活性的益生菌有效

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