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首页> 外文期刊>Journal of the Korean Society for Applied Biological Chemistry >Hypolipidemic, Hypoglycemic, and Antioxidative Effects of a New Pigmented Rice Cultivar 'Superjami' in High Fat-fed Mice
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Hypolipidemic, Hypoglycemic, and Antioxidative Effects of a New Pigmented Rice Cultivar 'Superjami' in High Fat-fed Mice

机译：新型色素水稻品种“ Superjami”在高脂喂养小鼠中的降血脂，降血糖和抗氧化作用

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摘要

Effects of newly-developed pigmented rice Superjami, in comparison with those of its parental cultivars (Heugjinjubyeo and Suweon 425) and ordinary brown rice, on the lipid and glucose metabolisms and antioxidative defense status in high fat-fed mice were investigated. The animals were randomly divided and given experimental diets for eight weeks: normal control, high fat, and high fat supplemented with ordinary brown, Heugjinjubyeo, Suweon 425 or Superjami rice powder. Their body weight, plasma lipid profile, blood glucose level, and lipid peroxidation were measured. The enzymes and hormones involved in the lipid and glucose metabolisms were also analyzed. High fat feeding significantly increased the body weight, total cholesterol, triglyceride, blood glucose, and lipid peroxidation in mice. On the other hand, diet supplementation of the rice samples, particularly Superjami, markedly reduced the body weight gain, improved the lipid and glucose profiles, and suppressed oxidative stress through regulation of hepatic lipogenesis and adipokine production, inhibition of glucose-regulating enzymes, and enhancement of antioxidant enzyme activities. Superjami has greater hypolipidemic, hypoglycemic, and antioxidant status-improving effects than its parental cultivars. This study provides the first evidence of the physiological effect of Superjami, which may be useful in the prevention and management of high fat diet-induced hyperlipidemia, hyperglycemia, and oxidative stress
机译：与其亲代品种（Heugjinjubyeo和Suweon 425）和普通糙米相比，新开发的色素大米Superjami对高脂喂养小鼠的脂质，葡萄糖代谢和抗氧化防御状态的影响进行了研究。将动物随机分成八周进行实验饮食：正常对照组，高脂肪和高脂肪，并补充普通棕，Heugjinjubyeo，Suweon 425或Superjami米粉。测量它们的体重，血浆脂质谱，血糖水平和脂质过氧化。还分析了参与脂质和葡萄糖代谢的酶和激素。高脂喂养显着增加了小鼠的体重，总胆固醇，甘油三酸酯，血糖和脂质过氧化作用。另一方面，通过调节肝脏脂肪生成和脂肪因子的产生，抑制葡萄糖调节酶的含量，补充大米样品（尤其是Superjami）的饮食，可显着降低体重增加，改善脂质和葡萄糖谱并抑制氧化应激。增强抗氧化酶的活性。与其亲本品种相比，Superjami具有更高的降血脂，降糖和抗氧化剂状态改善作用。这项研究提供了Superjami的生理效应的第一个证据，这可能有助于预防和控制高脂饮食引起的高脂血症，高血糖症和氧化应激

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