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首页> 外文期刊>Journal of the Korean Society for Applied Biological Chemistry >Anti-Diabetic Effects of Red Rose Flowers in Streptozotocin-Induced Diabetic Mice
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Anti-Diabetic Effects of Red Rose Flowers in Streptozotocin-Induced Diabetic Mice

机译：红玫瑰花朵对链脲佐菌素诱导的糖尿病小鼠的抗糖尿病作用

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摘要

Diabetes mellitus is a common chronic metabolic disease that is of increasing concern, because it frequently leads to complications such as cardiovascular diseases and cancer. Plants have been studied as a potential source for anti-diabetics to supplement dietary modifications, insulin, and other medications. The components of green tea polyphenols can be changed by processes such as browning. This processing method was applied to the red rose flower to determine whether the processed or non-processed rose flower has an anti-diabetic effect on the streptozotocin-induced diabetic mouse. Aqueous extracts of processed and non-processed rose flowers were analyzed using liquid chromatography/mass spectrometry. The results show that the polyphenol content decreased with browning. The hemoglobin Ale level, an indicator of long-term diabetes, in diabetic mice after administration of extracts of browned rose flowers for 24 and 48 h were lower than those after administration of extracts of non-browned rose flowers. Moreover, the activity of aspartate transaminase, which is often high in diabetic patients, was low in all groups treated with rose flowers, whether they were non-browned. or browned. Taken together, these results indicate that extracts from red rose flowers have long-term anti-diabetic effects, and that this effect is independent of the level of polyphenols in the extract
机译：糖尿病是一种日益受到关注的常见慢性代谢性疾病，因为它经常导致诸如心血管疾病和癌症的并发症。已经研究了植物作为抗糖尿病药的潜在来源，以补充饮食改良剂，胰岛素和其他药物。绿茶多酚的成分可以通过褐变等方法来改变。将此加工方法应用于红玫瑰花朵，以确定已加工或未加工的玫瑰花朵是否对链脲佐菌素诱导的糖尿病小鼠具有抗糖尿病作用。使用液相色谱/质谱法分析了已加工和未加工玫瑰花的水提物。结果表明，多酚含量随褐变而降低。糖尿病小鼠在服用褐玫瑰花提取物24小时和48小时后的血红蛋白Ale水平低于长期服用糖尿病患者的血红蛋白水平。此外，天冬氨酸转氨酶的活性通常在糖尿病患者中较高，而在所有用玫瑰花治疗的组中，无论其是否为非棕色，其活性均较低。或褐色。综上所述，这些结果表明，红玫瑰花朵的提取物具有长期的抗糖尿病作用，并且这种作用与提取物中多酚的含量无关。

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