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Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: an EEG event-related potential study.

机译:多动症儿童和自闭症儿童的错误和反馈处理:一项与脑电事件相关的潜在研究。

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OBJECTIVE: Performance monitoring was investigated in typically developing (TD) children, children with Autistic Spectrum Disorder (ASD), and Methylphenidate (Mph)-treated and medication-free children with Attention Deficit Hyperactivity Disorder (ADHD). METHODS: Subjects performed a feedback-based learning task. Event-related Potentials (ERPs) time locked to responses and feedback were derived from the EEG. RESULTS: Compared to the TD and ASD groups, the medication-free ADHD group showed a decreased response-locked Error Related Negativity (ERN) and error Positivity (Pe), particularly as learning progressed throughout the task. Compared to the medication-free ADHD group, the Methylphenidate-treated group showed a normalised Pe. All clinical groups showed or tended to show a decreased feedback-locked late positive potential to negative feedback. CONCLUSIONS: The ERPs suggest that medication-free children with ADHD, but not with ASD, have a diminished capacity to monitor their error responses when they are learning by performance feedback. This capacity partially 'normalises' in Mph-treated children with ADHD. Both children with ADHD and children with ASD are suggested being compromised in affective feedback processing. SIGNIFICANCE: This study shows that measuring ERPs of error and feedback processing is a useful method for (1) dissociating ADHD from ASD and (2) elucidating medication effects in ADHD on component processes of performance monitoring.
机译:目的:对发育中的儿童(TD),自闭症谱系障碍(ASD),哌醋甲酯(Mph)治疗和无药物治疗的注意缺陷多动障碍(ADHD)儿童进行了性能监测。方法:受试者执行基于反馈的学习任务。时间响应和反馈锁定的事件相关电位(ERP)来自脑电图。结果:与TD和ASD组相比,无药物的ADHD组表现出降低的响应锁定的错误相关负性(ERN)和错误正性(Pe),特别是在整个任务过程中学习进展的情况下。与无药物的ADHD组相比,哌醋甲酯治疗组的Pe正常。所有临床组均显示或倾向于显示降低的反馈锁定晚期阳性潜力至阴性反馈。结论:ERPs提示,在通过表现反馈进行学习时,患有ADHD但没有ASD但没有药物治疗的ADHD儿童监测其错误反应的能力有所减弱。在接受Mph治疗的多动症儿童中,这种能力部分“正常化”。建议ADHD患儿和ASD患儿在情感反馈处理中都受到影响。意义:这项研究表明,对错误和反馈处理的ERP进行测量是一种有用的方法(1)将ADHD与ASD分离,以及(2)阐明ADHD中药物对性能监测过程的影响。

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